1150561-61-7 Usage
Description
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is a complex organic compound characterized by its unique molecular structure. It features a pyridine ring with a methoxy group at the 2nd position, a trifluoromethyl group at the 3rd position, and a 1,3,2-dioxaborolan-2-yl group at the 5th position. 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is known for its potential applications in the pharmaceutical industry, particularly in the development of PI3K inhibitors.
Uses
Used in Pharmaceutical Industry:
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine is used as a building block for the synthesis of PI3K inhibitors. These inhibitors are crucial in the development of targeted therapies for various types of cancer, as PI3K plays a significant role in cell growth, survival, and proliferation. By incorporating this compound into the molecular structure of PI3K inhibitors, researchers can potentially enhance the efficacy and selectivity of these therapeutic agents, leading to improved treatment outcomes for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1150561-61-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,0,5,6 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1150561-61:
(9*1)+(8*1)+(7*5)+(6*0)+(5*5)+(4*6)+(3*1)+(2*6)+(1*1)=117
117 % 10 = 7
So 1150561-61-7 is a valid CAS Registry Number.
1150561-61-7Relevant articles and documents
Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors
Feng, Yifan,Duan, Weiming,Fan, Shu,Zhang, Hao,Zhang, San-Qi,Xin, Minhang
, (2019/08/20)
PI3Kδ is an intriguing target for developing anti-cancer agent. In this study, a new series of 4-(piperid-3-yl)amino substituted 6-pyridylquinazoline derivatives were synthesized. After biological evaluation, compounds A5 and A8 were identified as potent PI3Kδ inhibitors, with IC50 values of 1.3 and 0.7 nM, respectively, which are equivalent to or better than idelalisib (IC50 = 1.2 nM). Further PI3K isoforms selectivity evaluation showed that compound A5 afforded excellent PI3Kδ selectivity over PI3Kα, PI3Kβ and PI3Kγ. A8 exhibited superior PI3Kδ/γ selectivity over PI3Kα and PI3Kβ. Moreover, compounds A5 and A8 selectively exhibited anti-proliferation against SU-DHL-6 in vitro with IC50 values of 0.16 and 0.12 μM. Western blot analysis indicated that A8 could attenuate the AKTS473 phosphorylation. Molecular docking study suggested that A8 formed three key H-bonds action with PI3Kδ, which may account for its potent inhibition of PI3Kδ. These findings indicate that 4-(piperid-3-yl)amino substituted 6-pyridylquinazoline derivatives were potent PI3Kδ inhibitors with distinctive PI3K-isoforms and anti-proliferation profiles.
