115073-27-3Relevant articles and documents
Reactions of 6-acetyl-4-methyl-5-(1-pyrrolyl)-2-phenylthieno-[2,3-d] pyrimidine in heterocyclic synthesis: Convenient route to some Schiff's bases, chalcones, pyridines, pyridin-2(1H)-ones and 2H-pyran-2-one derivatives incorporating a 5-(1-pyrrolyl)-2-ph
Ho, Yuh-Wen,Yao, Wei-Hua
, p. 313 - 325 (2007/10/03)
Treatment of 6-acetyl-5-amino-4-methyl-2-phenylthieno[2,3-d]pyrimidine 3 with 2,5-dimethoxytetrahydrofuran afforded the 6-acetyl-5-(1-pyrrolyl)-4-methyl- 2-phenylthieno[2,3-d]pyrimidine 4, which can react with appropriate primary amines 5a-f to yield the
Synthesis of novel pyrrylthieno-[2,3-d]pyrimidines and related pyrrolo[1″,2″:1′,6′]pyrazino-[2′,3′:4,5] thieno[2,3-d]pyrimidines
Bakhite,Geies,El-Kashef
, p. 303 - 323 (2007/10/03)
4-Methyl-2-phenyl-5-(1-pyrryl)-6-substituted-thieno[2,3-d]pyrimidines (3a-c, 4a-c, 5a,b, and 6) have been synthesized. Some of the substituents in position 6 were used to build up different sulfur-, nitrogen-and/or oxygen-containing heterocyclic rings at that position. The 4-methyl- 2-phenyl-5-(1-pyrryl)-thieno[2,3-d]pyrimidine-6-carboazide (20) was also used as a key intermediate in the synthesis of the target pyrrolo[1″,2″:1′,6′]pyrazino[2′,3′:4, 5/thieno[2,3-d]pyrimidines.
3-Amino-1H-pyrazolopyrimidines and 3-Aminoisothiazolopyrimidines as Precursors of Tricyclic Heteroaromatic Systems Containing a Bridgehead Nitrogen Atom.
Golec, Julian M. C.,Scrowston, Richard M.
, p. 326 - 345 (2007/10/02)
3-Amino-4-methyl-6-phenyl-1H-pyrazolopyrimidine (3a) and 3-amino-4-methyl-6-phenylisothiazolopyrimidine (9a) have been prepared.The former reacts with bromoacetone or 3-bromopentane-2,4-dione, to give tricyclic systems (1a) or (13) containing an extra pyrazole or pyrimidine ring, respectively; in each case the newly formed ring contains a bridgehead nitrogen atom, derived from N-2 of the starting material.With the same reagents, the latter undergoes an interesting ring-opening reaction, for which possible mechanisms are proposed.In contrast, 3-amino-1,2-benzisothiazole does not undergo ring fission under similar conditions, but gives rise to tricyclic compounds containing a bridgehead nitrogen atom.