1153949-38-2

Basic information

• Product Name: 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile
• Synonyms: 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile
• CAS NO: 1153949-38-2
• Molecular Formula: C17H26BN3O2
• Molecular Weight: 315.21824
• Mol File: 1153949-38-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 471.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.13
• Storage Temp.: 2-8°C
• Solubility: DCM, Methanol
• PKA: 1.71±0.10(Predicted)
• CAS DataBase Reference: 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile(1153949-38-2)
• EPA Substance Registry System: 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile(1153949-38-2)

Safety Data

• Hazardous Substances Data: 1153949-38-2(Hazardous Substances Data)

Usage

Description

3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile is an organic compound that serves as a key intermediate in the synthesis of Ruxolitinib (R701995), a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor. 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile plays a crucial role in the development of pharmaceuticals targeting specific kinases involved in various diseases.
Used in Pharmaceutical Industry:
3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile is used as a chemical intermediate for the synthesis of Ruxolitinib, a medication indicated for the treatment of myeloproliferative neoplasms and psoriasis. Its role in the synthesis process is vital for creating a drug that can effectively inhibit the activity of JAK1 and JAK2 kinases, thus helping to manage the symptoms and progression of the diseases it is prescribed for.

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 591769-05-0 3-cyclopentyl-acrylonitrile 
• 872-53-7 cyclopentanealdehyde 
• 1269823-10-0 3-cyclopentyl-3-(4-iodo-1H-pyrazol-1-yl)propanenitrile 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 941688-05-7 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile 
• 1146629-84-6 (3R)-3-cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile 
• 1236033-24-1 (S)-3-cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile 
• 941685-39-8 3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxymethyl]-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile 

Relevant articles and documents

PYRAZOLYL PYRROLO[2,3-B]PYRMIDINE-5-CARBOXYLATE ANALOGS AND METHODS OF MAKING THE SAME

The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS

The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula (I).

4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS

The present invention provides substituted bicyclic heteroaryl compounds, 5 including, for example, 4-pyrazoIyI-N-arylpyrirnidin-2-arnines and 4-pyrazolyl-N-heteroarylpyτimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.formule :(1)