116013-81-1

Basic information

• Product Name: phenyl 4-ethylbenzenesulfonate
• Synonyms: phenyl 4-ethylbenzenesulfonate
• CAS NO: 116013-81-1
• Molecular Weight: 262.329
• Mol File: 116013-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl 4-ethylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 4-ethylbenzenesulfonate(116013-81-1)
• EPA Substance Registry System: phenyl 4-ethylbenzenesulfonate(116013-81-1)

Safety Data

• Hazardous Substances Data: 116013-81-1(Hazardous Substances Data)

Upstream product

• 2437-33-4 4-chlorobenzolsulfonsaeure-phenylester 
• 925-90-6 ethylmagnesium bromide 
• 2386-64-3 ethylmagnesium chloride 

Relevant articles and documents

Iron-catalyzed cross-coupling reactions of alkyl grignards with aryl chlorobenzenesulfonates

Aryl sulfonate esters are versatile synthetic intermediates in organic chemistry as well as attractive architectures due to their bioactive properties. Herein, we report the synthesis of alkyl-substituted benzenesulfonate esters by iron-catalyzed C(sp2)–C(sp3) cross-coupling of Grignard reagents with aryl chlorides. The method operates using an environmentally benign and sustainable iron catalytic system, employing benign urea ligands. A broad range of chlorobenzenesulfonates as well as challenging alkyl organometallics containing β-hydrogens are compatible with these conditions, affording alkylated products in high to excellent yields. The study reveals that aryl sulfonate esters are the most reactive activating groups for iron-catalyzed alkylative C(sp2)–C(sp3) cross-coupling of aryl chlorides with Grignard reagents.