1160293-75-3Relevant articles and documents
Enantioselective organocatalytic α-sulfamidation of aldehydes using sulfonyl azides
McGorry, Raymond J.,Allen, Stacey K.,Pitzen, Micha D.,Coombs, Thomas C.
supporting information, p. 4623 - 4627 (2017/11/15)
Enantioselective organocatalytic α-sulfamidation of unbranched aldehydes is described using MacMillan's second-generation imidazolidinone catalyst and o-nitrobenzenesulfonyl azide. The reactions are highly stereoselective (89.9–96.3% ee) with yields up to 71%. A strong correlation between aldehyde structure and product yield was found to exist, with 3-arylpropanals providing the best results. Application to functionalized amino acid synthesis is presented.