116253-76-0

Basic information

• Product Name: Quinoline, 8-(4-nitrophenoxy)-
• CAS NO: 116253-76-0
• Molecular Formula: C15H10N2O3
• Molecular Weight: 266.256
• Mol File: 116253-76-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Quinoline, 8-(4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 8-(4-nitrophenoxy)-(116253-76-0)
• EPA Substance Registry System: Quinoline, 8-(4-nitrophenoxy)-(116253-76-0)

Safety Data

• Hazardous Substances Data: 116253-76-0(Hazardous Substances Data)

Upstream product

• 17763-80-3 para-nitrophenyl triflate 
• 222713-64-6 8-((tert-butyldimethylsilyl)oxy)quinoline 
• 148-24-3 8-quinolinol 
• 586-78-7 para-nitrophenyl bromide 
• 350-46-9 4-Fluoronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 116253-63-5 4-(quinolin-8-yloxy)aniline 

Relevant articles and documents

Base-mediated N- And O-arylations of NH-containing heterocycles, heterocyclic amines and phenols

Nucleophilic substitution reactions of N-heterocycles such as imidazole, benzimidazole, indole and pyrazole as well as NH2 or OH containing heterocycles, with electron-deficient aryl halides in the presence of t-BuOK or K2CO3as base and DMSO as solvent are reported. A series of N-aryl azoles, unsymmetric diaryl ethers and diaryl amines were obtained in good yields.

ENTRY INHIBITORS OF THE HIV VIRUS

The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS. The compounds of formula (I) have the following structure: (I).

A general and efficient protocol for the synthesis of biaryl ethers from aryl silyl ethers using Cs2CO3

A general and efficient one-step procedure has been developed for the synthesis of biaryl ethers via direct coupling of electron-deficient arylhalides or aryl triflates to aryl t-butyldimethylsilyl (TBS) ethers using Cs 2CO3. The protocol was also applied to electron-rich arylhalides by addition of a catalytic amount of copper(I) iodide. The reaction is rapid and provides good to excellent yields.