116332-54-8

Basic information

• Product Name: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
• Synonyms: 4-Fluoro-N-methyl-N-methoxybenzamide;N-Methoxy-N-methyl-4-fluorobenzaldehyde;N-Methyl-N-methoxy-4-fluorobenzamide;Benzamide, 4-fluoro-N-methoxy-N-methyl-;4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(WXFC0878)
• CAS NO: 116332-54-8
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.181
• Mol File: 116332-54-8.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 301.553°C at 760 mmHg
• Flash Point: 136.174°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(116332-54-8)
• EPA Substance Registry System: 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(116332-54-8)

Safety Data

• Hazardous Substances Data: 116332-54-8(Hazardous Substances Data)

Usage

General Description

4-Fluoro-N-methoxy-N-methylbenzamide is a chemical compound with the molecular formula C9H10FNO2. It is a benzamide derivative with a fluorine atom at the 4-position and a methoxy and methyl group attached to the nitrogen. 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE is often used in medicinal chemistry as a building block for the synthesis of pharmaceuticals and research chemicals. It has potential use as an intermediate in the production of drugs that target the central nervous system and as a precursor for the development of novel therapeutic agents. Additionally, it may also have applications in the field of organic synthesis and drug discovery.

InChI:InChI=1/C9H10FNO2/c1-11(13-2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 456-22-4 4-Fluorobenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 201230-82-2 carbon monoxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 15226-74-1 dicobalt octacarbonyl 

Downstream Products

• 116332-55-9 3-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)propan-1-one 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 152122-41-3 2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone 
• 222306-54-9 (4-fluoro-phenyl)-(1H-indol-5-yl)-methanone 
• 366-62-1 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone 
• 223742-81-2 N-[3-(4-fluorobenzoyl)-4-pyridinyl]-2,2-dimethylpropanamide 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 158876-69-8 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone 
• 158876-70-1 2-(2-bromopyridin-4-yl)-1-(4-fluorophenyl)ethan-1-one 
• 709-24-0 1-(4-fluorophenyl)-1-pentanone 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 898759-71-2 (4-fluoro-phenyl)(oxazol-2-yl)methanone 
• 166895-16-5 N-[1-(4-fluorophenyl)-2-(pyridin-4-yl)ethylidene]hydroxylamine 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 

Relevant articles and documents

Photochromic bi-naphthopyrans

A series of novel 3-aryl-(3,3-diaryl-3H-naphtho[2,1-b]pyran-8-yl)-3H-naphtho[2,1-b]pyrans has been accessed from 6-bromo-2-naphthol via a four step transformation. Acylation of the dianion derived from the treatment of 6-bromo-2-naphthol with n-butyllithi

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes

An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph

Synthesis of secondary and tertiary amides without coupling agents from amines and potassium acyltrifluoroborates (KATs)

Although highly effective for most amide syntheses, the activation of carboxylic acids requires the use of problematic coupling reagents and is often poorly suited for challenging cases such as N-methyl amino acids. As an alternative to both secondary and tertiary amides, we report their convenient synthesis by the rapid oxidation of trifluoroborate iminiums (TIMs). TIMs are easily prepared by acid-promoted condensation of potassium acyltrifluoroborates (KATs) and amines and are cleanly and rapidly oxidized to amides with hydrogen peroxide. The overall transformation can be conducted either as a one-pot procedure or via isolation of the TIM. The unique nature of the neutral, zwitterionic TIMs makes possible the preparation of tertiary amides via an iminium species that would not be accessible from other carbonyl derivatives and can be conducted in the presence of unprotected functional groups including acids, alcohols and thioethers. In preliminary studies, this approach was applied to the late-stage modifications of long peptides and the iterative synthesis of short, N-methylated peptides without the need for coupling agents.