1164294-64-7

Basic information

• Product Name: 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-(isopropyldimethylsilanyloxy)-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione
• Synonyms: 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-(isopropyldimethylsilanyloxy)-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione
• CAS NO: 1164294-64-7
• Molecular Weight: 575.507
• Mol File: 1164294-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-(isopropyldimethylsilanyloxy)-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-(isopropyldimethylsilanyloxy)-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione(1164294-64-7)
• EPA Substance Registry System: 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-(isopropyldimethylsilanyloxy)-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione(1164294-64-7)

Safety Data

• Hazardous Substances Data: 1164294-64-7(Hazardous Substances Data)

Upstream product

• 1164294-57-8 2-[(3'R,5'S)-5'-(tert-butyldimethylsilanyloxy)-3'-fluoro-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 1164294-66-9 2-[(3'R,5'S)-1'-(4-bromobenzyl)-3'-fluoro-5'-hydroxy-2',6'-dioxopiperidin-3'-yl]isoindole-1,3-dione 

Relevant articles and documents

3'-Fluoro-5'-hydroxythalidomide and derivatives thereof

There are provided a novel 3′-fluoro-5′-hydroxythalidomide derivative and an optically active substance thereof A 3′-fluoro-5′-hydroxythalidomide derivative represented by the general formula [A]: wherein R1, R2 and R3 are each a hydrogen atom; and X is C═O, and an optically active substance thereof. As analogs of thalidomide, the 3′-fluoro-5′-hydroxythalidomide derivatives are useful in the treatment of erythema nodosum of Hansen's disease, prurigo, rheumatism, Crohn's disease, graft-versus-host disease, Behcet's disease, myeloma, aphtha ulcer and the like. Further, the 3′-fluoro-5′-hydroxythalidomide derivative is useful as a drug used for treatment of multiple myeloma, TNF-α related diseases and the like.