116718-51-5

Basic information

• Product Name: 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one
• Synonyms: 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one
• CAS NO: 116718-51-5
• Molecular Weight: 282.296
• Mol File: 116718-51-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one(116718-51-5)
• EPA Substance Registry System: 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one(116718-51-5)

Safety Data

• Hazardous Substances Data: 116718-51-5(Hazardous Substances Data)

Upstream product

• 93434-89-0 1-(2,4-dihydroxy-3-methylphenyl)-2-(4-methoxyphenyl)ethanone 
• 608-25-3 2-methylbenzene-1,3-diol 
• 104-01-8 4-Methoxyphenylacetic acid 
• 104-47-2 p-methoxybenzylnitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 124-63-0 methanesulfonyl chloride 
• 853927-76-1 7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-8-carboxaldehyde 

Downstream Products

• 139256-08-9 7-hydroxy-3-(4-hydroxyphenyl)-8-methyl-4H-chromen-4-one 
• 903862-40-8 7-(2-bromoethoxy)-8-methyl-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 1425265-15-1 (1R,5S)-3-(2-{[8-methyl-3-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl]oxy}ethyl)-1,2,3,4,5,6-hexahydro-8H-1,5-methanepyrido[1,2-a][1,5]diazocin-8-one hydrochloride 
• 1309445-42-8 C₃₁H₃₂O₁₃ 
• 116718-67-3 3,4-Dihydro-7-hydroxy-8-methyl-3-(4-methoxyphenyl)-2H-1-benzopyran 
• 288266-76-2 7-acetoxy-3-(4-acetoxy-phenyl)-8-methyl-chromen-4-one 
• 262600-98-6 7-acetoxy-8-<2,2-bis-(ethoxycarbonyl)ethyl>-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-99-7 8-(2-carboxyethyl)-7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-97-5 8-bromomethyl-7-acetoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-96-4 7-acetoxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 

Relevant articles and documents

Production of isoflavone derivatives

Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.

Synthesis of haptens and conjugates for ELISAs of phytoestrogens. Development of the immunological tests

Seven carboxylic acid haptens of isoflavonoids were synthesized, with the spacer arm on the oxygen atom at the C7 position for one series, with formononetin, daidzein, equol, biochanin A, and genistein, and at the C8 position for a second series, with only formononetin and daidzein. The different haptens were coupled to bovine serum albumin (BSA) and to swine thyroglobulin (Thyr). Polyclonal antibodies were generated against the BSA conjugates. Enzyme-linked immunosorbent assays (ELISAs) were developed based on competition between free phytoestrogens and the Thyr-hapten conjugates for specific antibodies. IC50 values of the standard curves ranged between 0.8 and 20 ng/mL that is, 0.3 and 9.2 pmol/well. The antibodies obtained should be useful for assays in vegetable matter as well as in biological fluids after a separation step. These ELISAs should be valuable also in the food industry to control phytoestrogen concentrations prior to and after processing.