117953-30-7Relevant articles and documents
Exogenous-oxidant-free electrochemical oxidative C-H sulfonylation of arenes/heteroarenes with hydrogen evolution
Yuan, Yong,Yu, Yi,Qiao, Jin,Liu, Pan,Yu, Banying,Zhang, Wukun,Liu, Huilin,He, Min,Huang, Zhiliang,Lei, Aiwen
, p. 11471 - 11474 (2018/10/20)
An efficient and environmentally benign electrochemical oxidative radical C-H sulfonylation of arenes/heteroarenes was developed in this work. A series of significant diarylsulfones were prepared under mild catalyst- and exogenous-oxidant-free reaction conditions, which efficiently avoid the issues of desulfonylation or over-reduction of sulfonyl groups.
Isomerization-free sulfonylation and its application in the synthesis of PHA-565272A
Fleck, Thomas J.,Chen, Jiong Jack,Lu, Cuong V.,Hanson, Kari J.
, p. 334 - 338 (2012/12/22)
FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.
