1181455-54-8

Basic information

• Product Name: (E)-5-chloro-2-styrylaniline
• Synonyms: (E)-5-chloro-2-styrylaniline
• CAS NO: 1181455-54-8
• Molecular Weight: 229.709
• Mol File: 1181455-54-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-5-chloro-2-styrylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-chloro-2-styrylaniline(1181455-54-8)
• EPA Substance Registry System: (E)-5-chloro-2-styrylaniline(1181455-54-8)

Safety Data

• Hazardous Substances Data: 1181455-54-8(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 6828-35-9 5-chloro-2-iodoaniline 
• 823-57-4 2-bromo-5-chloroaniline 
• 1181455-53-7 (E)-4-chloro-2-nitro-1-styrylbenzene 

Downstream Products

• 1374753-84-0 6-chloro-2-phenyl-1-(p-toluenesulfonyl)indole 

Relevant articles and documents

Silver(I)-mediated C-H amination of 2-alkenylanilines: Unique solvent-dependent migratory aptitude

A highly effective silver(I)-mediated C-H amination of 2-alkenylanilines has been developed to afford a diverse range of substituted indoles. High functional group tolerance, broad substrate scope, simple/fast/high-yielding reaction, and recovery/reuse of the inexpensive silver oxidant are noteworthy. Furthermore, an uncommon migratory process of β-monosubstituted 2-alkenylanilines with solvent-dependence was demonstrated.

Metal-free C-H amination for indole synthesis

An effective metal-free C-H amination of N-Ts-2-alkenylanilines by using DDQ as an oxidant has been developed to afford a diverse range of substituted indoles. This protocol is operationally simple and robust, obviates the need of expensive transition-metal catalysts, and offers a broad substrate scope. A mechanism involving a radical cation generated by SET and a migratorial process via a phenonium ion intermediate is proposed.