1182843-51-1

Basic information

• Product Name: 4-methoxy-1-(2-nitrobenzyl)-1H-benzo[d][1,2,3]triazole
• Synonyms: 4-methoxy-1-(2-nitrobenzyl)-1H-benzo[d][1,2,3]triazole
• CAS NO: 1182843-51-1
• Molecular Weight: 284.274
• Mol File: 1182843-51-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methoxy-1-(2-nitrobenzyl)-1H-benzo[d][1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-1-(2-nitrobenzyl)-1H-benzo[d][1,2,3]triazole(1182843-51-1)
• EPA Substance Registry System: 4-methoxy-1-(2-nitrobenzyl)-1H-benzo[d][1,2,3]triazole(1182843-51-1)

Safety Data

• Hazardous Substances Data: 1182843-51-1(Hazardous Substances Data)

Upstream product

• 95668-86-3 1-(azidomethyl)-2-nitrobenzene 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 
• 612-23-7 2-nitrobenzyl chloride 

Relevant articles and documents

Microwave-assisted benzyne-click chemistry: preparation of 1H-benzo[d][1,2,3]triazoles

The benzotriazoles were prepared by three-component and two-component microwave-assisted [3+2] cycloadditions of various azides to benzyne, 3-methoxybenzyne, and 4,5-difluorobenzyne. In the three-component reaction, the aryne is generated, in the presence of an azide prepared in situ, by the reaction of an o-(trimethylsilylaryl) triflate with either CsF or KF/18-Crown-6. However, in the two-component reactions, a freshly prepared azide is added to the reaction vessel prior to aryne generation. Good to excellent yields of benzotriazoles were obtained in 15-20 min when the microwave-assisted reactions were carried out at 125 °C. These reaction times are significantly faster than similar reactions carried out using conventional heating.