118287-89-1 Usage
Description
2-Chloro-4-diethoxymethyl-pyridine is a chlorinated derivative of the pyridine family of chemical compounds, characterized by the presence of two diethoxymethyl groups. It is a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals, serving as a building block for the production of a range of drugs and agricultural chemicals.
Uses
Used in Pharmaceutical Industry:
2-Chloro-4-diethoxymethyl-pyridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-4-diethoxymethyl-pyridine is utilized as a precursor in the production of agricultural chemicals. Its incorporation into these products can enhance their effectiveness in protecting crops and controlling pests.
Safety Precautions:
Due to its toxic nature, 2-Chloro-4-diethoxymethyl-pyridine should be handled with care to prevent ingestion or inhalation. Proper safety measures, including the use of personal protective equipment and secure storage, should be implemented to ensure the well-being of those working with this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 118287-89-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,8 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 118287-89:
(8*1)+(7*1)+(6*8)+(5*2)+(4*8)+(3*7)+(2*8)+(1*9)=151
151 % 10 = 1
So 118287-89-1 is a valid CAS Registry Number.
118287-89-1Relevant articles and documents
Synthesis of protected 5-formylpyrido[2,3-d] pyrimidine via a 2,3,4-trisubstituted pyridine using an ortho-litmation strategy; applicationtothe synthesis of a folate derivative
Watson, Samuel E.,Markovich, Anatoly
, p. 2149 - 2155 (1998)
A convenient route for the preparation of a protected 5-formylpyrido[2,3-d]pyrimidine from 2,3,4-trisubstituted pyridines has been developed. The readily available diethylacetal of pyridinc 4-carboxaldehyde is chlorinated at the 2-position and then treated with LDA and methyl chloroformate to give a 2,3,4-trisubstituted pyridine (12). Treatment of 12 with guanidine hydrochloride gives the pyrido[23-rf]pyrimidine in good yield. A 4-aminobenzoylglutamic acid side chain is installed by means of a reductive amination step to provide a 5-substituted derivative that is, after deprotection, a confonnationally unrestricted analog of 5,10-methylenetetrahydrofolate(1), the natural co-factor for thymidylate synthase, an important chemotherapeutic target in the treatment of cancer.
