1184953-70-5

Basic information

• Product Name: N-methyl-2-iodo-4-fluorophenylamine
• Synonyms: N-methyl-2-iodo-4-fluorophenylamine
• CAS NO: 1184953-70-5
• Molecular Weight: 251.042
• Mol File: 1184953-70-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-methyl-2-iodo-4-fluorophenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-iodo-4-fluorophenylamine(1184953-70-5)
• EPA Substance Registry System: N-methyl-2-iodo-4-fluorophenylamine(1184953-70-5)

Safety Data

• Hazardous Substances Data: 1184953-70-5(Hazardous Substances Data)

Upstream product

• 61272-76-2 4-fluoro-2-iodoaniline 
• 77-78-1 dimethyl sulfate 
• 917-54-4 methyllithium 
• 74-88-4 methyl iodide 

Downstream Products

• 1184953-32-9 4-(((5-Fluoro-1-methyl-2-(triethylsilyl)-1H-indol-3-yl)methoxy)methyl)-N,N-dimethyl-1-phenylcyclohexanamine 
• 124958-74-3 1-(5-fluoro-2-(methylamino)phenyl)ethan-1-one 
• 773-91-1 5-fluoro-1-methylisatin 

Relevant articles and documents

Cycloisomerization of Carbamoyl Chlorides in Hexafluoroisopropanol: Stereoselective Synthesis of Chlorinated Methylene Oxindoles and Quinolinones

Hexafluoroisopropanol (HFIP) was employed as an additive for the generation of 3-(chloromethylene)oxindoles via the chloroacylation of alkyne-tethered carbamoyl chlorides. This reaction avoids the use of a metal catalyst and accesses products in high yields and stereoselectivities. Additionally, this reaction is scalable and proved amenable to a series of product derivatizations, including the synthesis of nintedanib. The reactivity of alkene-tethered carbamoyl chlorides with hexafluoroisopropanol (HFIP) was harnessed towards the synthesis of 2-quinolinones.

A catalyst-free and additive-free method for the synthesis of benzothiazolethiones from: O -iodoanilines, DMSO and potassium sulfide

Under catalyst-free and additive-free conditions, a novel, convenient, eco-friendly method for the synthesis of benzothiazolethiones has been developed. The three-component reaction of o-iodoanilines and K2S with DMSO proceeded smoothly and the corresponding benzothiazolethiones were obtained with good isolated yields. Meanwhile, this method could be used for the synthesis of thioureas from primary diamines. Furthermore, mechanism research showed that DMSO not only functioned as a carbon source, but also as a mild oxidant in this reaction.

Silver-catalyzed incorporation of carbon dioxide into o-alkynylaniline derivatives

Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO2 into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C-C triple bond.