1186222-22-9

Basic information

• Product Name: 2-bromo-5-(4-tert-butylphenyl)-1,1-difluoro-4-methylpent-1-en-3-yl acetate
• Synonyms: 2-bromo-5-(4-tert-butylphenyl)-1,1-difluoro-4-methylpent-1-en-3-yl acetate
• CAS NO: 1186222-22-9
• Molecular Weight: 389.28
• Mol File: 1186222-22-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-5-(4-tert-butylphenyl)-1,1-difluoro-4-methylpent-1-en-3-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-(4-tert-butylphenyl)-1,1-difluoro-4-methylpent-1-en-3-yl acetate(1186222-22-9)
• EPA Substance Registry System: 2-bromo-5-(4-tert-butylphenyl)-1,1-difluoro-4-methylpent-1-en-3-yl acetate(1186222-22-9)

Safety Data

• Hazardous Substances Data: 1186222-22-9(Hazardous Substances Data)

Upstream product

• 430-85-3 1,1-dibromo-2,2-difluoroethylene 
• 108-24-7 acetic anhydride 
• 80-54-6 lilial 

Downstream Products

• 1186222-32-1 1-(tert-butyl)-4-(5,5-difluoro-2-methylpenta-3,4-dien-1-yl)benzene 

Relevant articles and documents

Facile synthesis of substituted 1,1-difluoroallenes via carbonyl difluorovinylidenation

Two methods for the difluorovinylidenation of carbonyl compounds have been developed to synthesize 1,1-difluoroallenes bearing various substituents. The reaction of 1-bromo-2,2-difluorovinyllithium, generated from 1,1-dibromo-2,2-difluoroethylene and n-butyllithium, with aldehydes or ketones, and subsequent acetylation, gives 2-bromo-3,3-difluoroallylic acetates. Elimination of these acetates with n-butyllithium affords 1,1-difluoroallenes in high yield. 3,3-Difluoro-2-iodoallylic acetates are similarly prepared from aldehydes or ketones on treatment with 2,2-difluoro-1-iodovinyllithium, generated from 1,1,1-trifluoro-2-iodoethane and lithium diisopropylamide, followed by acetylation. These acetates readily undergo elimination with zinc metal to afford 1,1-difluoroallenes in high yield. Georg Thieme Verlag Stuttgart · New York.