1186615-62-2Relevant articles and documents
Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase
Hast, Michael A.,Fletcher, Steven,Cummings, Christopher G.,Pusateri, Erin E.,Blaskovich, Michelle A.,Rivas, Kasey,Gelb, Michael H.,Van Voorhis, Wesley C.,Sebti, Said M.,Hamilton, Andrew D.,Beese, Lorena S.
, p. 181 - 192 (2009)
Protein farnesyltransferase (FTase) catalyzes an essential posttranslational lipid modification of more than 60 proteins involved in intracellular signal transduction networks. FTase inhibitors have emerged as a significant target for development of antic