1187577-25-8

Basic information

• Product Name: 6,7-dimethoxy-3-(3-trifluoromethylbenzyl)-3,4-dihydro-1H-quinolin-2-one
• Synonyms: 6,7-dimethoxy-3-(3-trifluoromethylbenzyl)-3,4-dihydro-1H-quinolin-2-one
• CAS NO: 1187577-25-8
• Molecular Weight: 365.352
• Mol File: 1187577-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,7-dimethoxy-3-(3-trifluoromethylbenzyl)-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-3-(3-trifluoromethylbenzyl)-3,4-dihydro-1H-quinolin-2-one(1187577-25-8)
• EPA Substance Registry System: 6,7-dimethoxy-3-(3-trifluoromethylbenzyl)-3,4-dihydro-1H-quinolin-2-one(1187577-25-8)

Safety Data

• Hazardous Substances Data: 1187577-25-8(Hazardous Substances Data)

Upstream product

• 454-87-5 3-(trifluoromethyl)benzenediazonium tetrafluoroborate 

Relevant articles and documents

Preparation of 2-Quinolones by sequential heck reduction-cyclization (HRC) reactions by using a multitask palladium catalyst

One-pot sequential Heck reduction-cyclization (HRC) reactions leading to the synthesis of substituted 2-quinolones have been developed by using a heterogeneous or mixed homogeneous/heterogeneous multitask palladium catalyst with charcoal as a support. The whole sequence occurs under very mild conditions without the need for additives (ligand or base) by taking advantage of the high reactivity of aryldiazonium salts as "super electrophiles". Recycling experiments showed that the reused heterogeneous Pd°/C catalyst was not able to promote another HRC sequence but was, however, still highly active for hydrogenation, hydrodehalogenation, as well as hydrogenolysis reactions.