1187945-05-6 Usage
Description
Regorafenib Impurity 6, also known as 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid, is a chemical compound derived from the parent drug Regorafenib. It is a potential impurity that may be present during the synthesis or manufacturing process of Regorafenib, a multikinase inhibitor used in the treatment of various types of cancer.
Uses
Used in Pharmaceutical Industry:
Regorafenib Impurity 6 is used as a reference material for the development and validation of analytical methods in the pharmaceutical industry. It helps in the identification, quantification, and control of impurities in the final drug product, ensuring the quality, safety, and efficacy of Regorafenib.
Used in Research and Development:
Regorafenib Impurity 6 serves as an important compound in the research and development of new drugs and therapies. It can be used to study the structure-activity relationship, pharmacokinetics, and pharmacodynamics of Regorafenib and its analogs, contributing to the advancement of cancer treatment options.
Used in Quality Control:
Regorafenib Impurity 6 is used as a quality control standard in the pharmaceutical industry. It is essential for the routine testing and monitoring of the purity and potency of Regorafenib, ensuring that the drug meets the required specifications and regulatory standards.
Used in Regulatory Compliance:
Regorafenib Impurity 6 plays a crucial role in regulatory compliance, as it is required for the registration and approval of Regorafenib by regulatory authorities. It helps in demonstrating the drug's safety and efficacy, as well as the manufacturer's ability to control and minimize impurities in the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 1187945-05-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,4 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1187945-05:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*4)+(3*5)+(2*0)+(1*5)=196
196 % 10 = 6
So 1187945-05-6 is a valid CAS Registry Number.
1187945-05-6Relevant articles and documents
PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR
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, (2019/12/12)
Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is -NH-phenyl-CH2-O-; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., -OC(O)-. ????????Lacto-XAN-PABC-Z?????(Formula A)
