118958-80-8

Basic information

• Product Name: Benzene, 2-fluoro-1-methoxy-4-(2-nitroethenyl)-
• CAS NO: 118958-80-8
• Molecular Formula: C9H8FNO3
• Molecular Weight: 197.166
• Mol File: 118958-80-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 2-fluoro-1-methoxy-4-(2-nitroethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-fluoro-1-methoxy-4-(2-nitroethenyl)-(118958-80-8)
• EPA Substance Registry System: Benzene, 2-fluoro-1-methoxy-4-(2-nitroethenyl)-(118958-80-8)

Safety Data

• Hazardous Substances Data: 118958-80-8(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 351-54-2 3-fluoro-p-anisaldehyde 

Downstream Products

• 951745-15-6 1-tert-butoxycarbonyl-4-(5-(3-fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine 
• 458-40-2 2-(3-fluoro-4-methoxyphenyl)ethan-1-amine 
• 118958-85-3 N-ethyl-N-propionyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-81-9 N-ethoxycarbonyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-84-2 N-methyl-N-propionyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-83-1 N-methyl-N-acetyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-82-0 N-acetyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-89-7 N,N-di-n.propyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-92-2 N-ethyl-N-n.propyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-91-1 N-methyl-N-n.propyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-88-6 N,N-diethyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 118958-90-0 N-ethyl-N-methyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 
• 52569-08-1 [2-(3-fluoro-4-methoxyphenyl)ethyl](methyl)amine 
• 118958-86-4 N-ethyl-2-(3-fluoro-4-methoxyphenyl)ethylamine 

Relevant articles and documents

6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER

The present invention discloses 6,7-dihydro-5H-pyrido[2,3- c]pyridazine, 1,2,3,4-tetrahydroquinoline, 1H-indole, 3,4- dihydro-2H-1,4-benzoxazine, 1H-pyrrolo[2,3-b]pyridin-1-yl, 7H- pyrrolo[2,3-c]pyridazine, 5H,6H,7H,8H,9H-pyridazino[3,4-b]azepine derivatives and related compounds of formula (I) as Bcl-xL protein inhibitors for use as pro-apoptotic agents for treating cancer, autoimmune diseases or immune system diseases. Formula (I). The description discloses the preparation of exemplary compounds (e.g. pages 113 to 354 examples 1 to 221) as well as pharmacological studies with relevant data (e.g. pages 355 to 367; examples A to E; tables 1 to 5). Exemplary compounds are e.g. 2-{6-[(1,3-benzothiazol-2-yl) amino]-1,2,3,4-tetrahydroquinolin-1-yl}-1,3-thiazole-4-carboxylic acid (example 1) or e.g. 3-{1-[(adamantan-1-yl)methyl]-5- methyl-1H-pyrazol-4-yl}-6-{3-[(1,3-benzothiazol-2-yl)amino]-4- methyl-5H,6H,7H,8H-pyrido[2,3-c]pyridazin-8-yl]pyridine-2-carboxylic acid (example 24).

Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes

An operationally simple and mild one-pot protocol for the synthesis of a variety of 3,5-diarylpyridines from β-nitrostyrenes was achieved by using elemental iron. This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation followed by trimolecular condensation with concomitant debenzylative aromatization. By employing this method, a series of symmetrical and unsymmetrical 3,5-diarylpyridines were synthesized with good to excellent yields. In addition, this method was also utilized for the synthesis of Sch-21418, an anti-inflammatory agent on gram scale.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.