119-24-4 Usage
Uses
Different sources of media describe the Uses of 119-24-4 differently. You can refer to the following data:
1. Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama
te synthetase.
2. Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.
General Description
Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Enzyme inhibitor
This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.
Purification Methods
Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]
Check Digit Verification of cas no
The CAS Registry Mumber 119-24-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119-24:
(5*1)+(4*1)+(3*9)+(2*2)+(1*4)=44
44 % 10 = 4
So 119-24-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
119-24-4Relevant articles and documents
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Hultquist et al.
, p. 23 (1948)
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A step-wise synthetic approach is necessary to access γ-conjugates of folate: Folate-conjugated prodigiosenes
Figliola, Carlotta,Marchal, Estelle,Groves, Brandon R.,Thompson, Alison
, p. 14078 - 14092 (2019/05/21)
Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate. We herein present a step-wise route to the preparation of nine folate conjugate
Site-specific folate conjugation to a cytotoxic protein
Smith, Bryan D.,Higgin, Joshua J.,Raines, Ronald T.
experimental part, p. 5029 - 5032 (2011/10/09)
Conjugation to folic acid is known to enhance the uptake of molecules by human cells that over-produce folate receptors. Variants of bovine pancreatic ribonuclease (RNase A) that have attenuated affinity for the endogenous ribonuclease inhibitor protein (
PROCESSES FOR MAKING EPOTHILONE COMPOUNDS AND ANALOGS
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Page/Page column 47, (2009/01/20)
The present invention relates to processes for making epothilone compounds and analogs thereof, such as epi-epothilone A or epi-epothilone B, and aziridinyl-epothilone analogs.