119254-71-6

Basic information

• Product Name: methyl 2-chloro-3-phenoxypropanoate
• CAS NO: 119254-71-6
• Molecular Weight: 214.649
• Mol File: 119254-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-chloro-3-phenoxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloro-3-phenoxypropanoate(119254-71-6)
• EPA Substance Registry System: methyl 2-chloro-3-phenoxypropanoate(119254-71-6)

Safety Data

• Hazardous Substances Data: 119254-71-6(Hazardous Substances Data)

Upstream product

• 80-63-7 methyl 2-chloroacrylate 
• 108-95-2 phenol 

Relevant articles and documents

AMINO ACIDS; 13. INVESTIGATIONS ON THE SYNTHESIS OF DL-SERINE FROM α-HALOACRYLIC ACID DERIVATIVES

The alkoxide-catalyzed addition of alcohols 2 to α-chloroacrylonitrile (1) at -35 degC gives rise to 3-alkoxy-2-chloropropanenitriles 3; at 0-5 degC with excess 2 alkyl 3-alkoxy-2-chloropropanimidates 4 are obtained.The yields of 3 or 4 decrease with increasing pKa values of the alcohols 2.In the basecatalyzed addition of phenols 5 to 1, a temperature-dependent addition equilibrium is set up in which the position of equilibrium is shifted in favour of the addition products 6 with increasing pKa values of 5.The 3-alkoxy-2-chloropropanoates 8, which are readily accessible by hydrolysis of 4, react smoothly with sodium azide in the presence of a phase transfer catalyst to furnish the 3-alkoxy-2-azidopropanoates 10.Starting from benzyl 2-azido-3-benzyloxy-propanoate (10b), the specific syntheses of DL-serine (14), DL-serine hydrochloride (14*HCl), DL-serine methyl ester hydrochloride (13a*HCl), O-benzyl-DL-serine (12b), and O-benzyl-DL-serine benzyl ester hydrochloride (11b*HCl) are possible by variation of the hydrogenation conditions.