119327-20-7Relevant articles and documents
Staudinger ligation: a peptide from a thioester and azide.
Nilsson,Kiessling,Raines
, p. 1939 - 1941 (2007/10/03)
[reaction: see text] The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.