1197215-49-8

Basic information

• Product Name: 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one
• Synonyms: 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one
• CAS NO: 1197215-49-8
• Molecular Weight: 554.553
• Mol File: 1197215-49-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(1197215-49-8)
• EPA Substance Registry System: 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(1197215-49-8)

Safety Data

• Hazardous Substances Data: 1197215-49-8(Hazardous Substances Data)

Upstream product

• 357194-03-7 2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one 
• 3188-13-4 ethyl chloromethyl ether 
• 2051-90-3 Dichlorodiphenylmethane 
• 117-39-5 quercetol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1197215-50-1 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one 
• 1197215-51-2 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-bis(methoxymethoxy)-4H-chromen-4-one 
• 603-61-2 tamarixetin 

Relevant articles and documents

Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation

Preclinical Research Using a high-throughout screening approach, the anticancer activities of 16 O-methylated (OMe) analogs of quercetin were assessed. The structure-activity relationships showed that OMe moieties at the 4′ and/or 7 positions were important for maintaining inhibitory activities against the 16 cancer cell lines. Furthermore, when the OH groups at the 3′ and 4′ positions were both replaced by OMe moieties, anticancer activity was enhanced.

An efficient partial synthesis of 4'-O-methylquercetin via regioselective protection and alkylation of quercetin

An efficient partial 5-step synthesis of 4'-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective pr