119824-66-7

Basic information

• Product Name: N-(2-Phenoxyacetyl)guanosine
• Synonyms: N-(2-Phenoxyacetyl)guanosine;N2-Phenoxyacetylguanosine;N2-PAC-rG
• CAS NO: 119824-66-7
• Molecular Formula: C₁₈H₁₉N₅O₇
• Molecular Weight: 417.37276
• Mol File: 119824-66-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 159-160 °C
• Appearance: /
• Density: 1.76±0.1 g/cm3(Predicted)
• PKA: 8.97±0.20(Predicted)
• CAS DataBase Reference: N-(2-Phenoxyacetyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Phenoxyacetyl)guanosine(119824-66-7)
• EPA Substance Registry System: N-(2-Phenoxyacetyl)guanosine(119824-66-7)

Safety Data

• Hazardous Substances Data: 119824-66-7(Hazardous Substances Data)

Usage

General Description

N-(2-Phenoxyacetyl)guanosine is a chemical compound that contains a guanosine base linked to a 2-phenoxyacetyl group. It is a modified nucleoside that has potential applications in pharmaceutical and biochemical research. The compound may exhibit unique properties due to its modified structure, which could potentially affect its interactions with biological systems. N-(2-Phenoxyacetyl)guanosine may also have potential therapeutic applications, such as in the development of new drugs for the treatment of various diseases. Further research into its properties and potential applications is needed to fully understand the potential uses of this chemical compound.

Upstream product

• 701-99-5 Phenoxyacetyl chloride 
• 118-00-3 G 
• 34079-68-0 2,6-diamino-9-(β-D-arabinofuranosyl)-purine 
• 53274-35-4 2',3',5'-O-Trisguanosine 
• 14316-61-1 phenoxyacetic anhydride 
• 375345-66-7 phenoxyacetyl-1-O-benzotriazolide 

Downstream Products

• 131474-72-1 N²-phenoxyacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 128191-50-4 5'-monomethxytrityl-N²-phenoxyacetyl-3'-triisopropylsilylguanosine 
• 119824-67-8 5'-monomethxytrityl-N²-phenoxyacetyl-2'-triisopropylsilylguanosine 
• 119824-68-9 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-4-triisopropylsilanyloxy-tetrahydro-furan-3-yl ester methyl ester 
• 1293390-55-2 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 1293390-63-2 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 
• 1293390-67-6 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1293390-74-5 N₂-(phenoxyacetyl)-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] 
• 1370348-30-3 [(2S,6R)-6-{N²-(phenoxyacetyl)-O⁶-(2-cyanoethyl)guanin-9-yl}-4-tritylmorpholin-2-yl]methyl dimethylphosphoramidochloridate 
• 1370348-34-7 N⁹-[(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2-yl]-N²-(phenoxyacetyl)-O⁶-(2-cyanoethyl)guanine 
• 1370348-33-6 N⁹-[(2R,6S)-6-{(tert-butyldimethylsilyloxy)methyl}-4-tritylmorpholin-2-yl]-N²-(phenoxyacetyl)-O⁶-(2-cyanoethyl)guanine 
• 1370348-32-5 N⁹-[(2R,6S)-6-{(tert-butyldimethylsilyloxy)methyl}-4-tritylmorpholin-2-yl]-N²-(phenoxyacetyl)-O⁶-(2,4,6-triisopropylbenzenesulfonyl)guanine 

Relevant articles and documents

Transient silylation of the guanosine O6 and amino groups facilitates N-acylation

(Matrix Presented) The formation of a guanosine derivative silylated at both the O6 and amino groups was identified by 15N NMR. This intermediate allows facile reaction with acetyl chloride or phenoxyacetyl chloride to give in high yield the co

Morpholino Nucleic Acid Derivatives

The present invention provides a useful morpholino nucleic acid derivative for synthesizing a morpholino nucleic acid oligomer. The present invention provides a compound represented by the following general formula (1) or a salt thereof. Here, R1 /s

High yield protection of purine ribonucleosides for phosphoramidite RNA synthesis

We report high yield procedures for protection of purine ribonucleosides based on a reaction which allows concomitant highly regiospecific 2'-silylation and 3'-phosphitylation. Subsequent cleavage of the H-phosphonate monoester moiety without silyl migration provides intermediates ready for phosphitylation by standard methods to give fully protected phosphoramidites.