1201177-73-2

Basic information

• Product Name: C₂₂H₃₂Cl₂N₇O₂⁽¹⁺⁾*F₆P^(1-)
• CAS NO: 1201177-73-2
• Molecular Weight: 642.412
• Mol File: 1201177-73-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₂Cl₂N₇O₂⁽¹⁺⁾*F₆P^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₂Cl₂N₇O₂⁽¹⁺⁾*F₆P^(1-)(1201177-73-2)
• EPA Substance Registry System: C₂₂H₃₂Cl₂N₇O₂⁽¹⁺⁾*F₆P^(1-)(1201177-73-2)

Safety Data

• Hazardous Substances Data: 1201177-73-2(Hazardous Substances Data)

Upstream product

• 146940-46-7 N-(2-Dimethylaminoethyl)-3,5-diamino-6-chloropyrazine-2-carboxamide 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 1201179-65-8 Br^(1-)*C₁₃H₂₅ClN₇O⁽¹⁺⁾ 
• 1357514-63-6 Br^(1-)*C₂₁H₂₇ClN₇O₃⁽¹⁺⁾ 

Relevant articles and documents

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational design hypothesis a series of quaternary amines were prepared and evaluated for their ability to block ion transport via ENaC in human bronchial epithelial cells (HBECs). Compound 11 has an IC50 of 200 nM and is efficacious in the Guinea-pig tracheal potential difference (TPD) model of ENaC blockade with an ED50 of 44 μg kg-1 at 1 h. As such, pyrazinoyl quaternary amines represent the first examples of a promising new class of human ENaC blockers.