1205-89-6

Basic information

• Product Name: 1-(4-methylphenyl)-3-prop-2-en-1-ylthiourea
• CAS NO: 1205-89-6
• Molecular Formula: C₁₁H₁₄N₂S
• Molecular Weight: 206.3073
• Mol File: 1205-89-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 299.6°C at 760 mmHg
• Flash Point: 135°C
• Density: 1.123g/cm³
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 1-(4-methylphenyl)-3-prop-2-en-1-ylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-3-prop-2-en-1-ylthiourea(1205-89-6)
• EPA Substance Registry System: 1-(4-methylphenyl)-3-prop-2-en-1-ylthiourea(1205-89-6)

Safety Data

• Hazardous Substances Data: 1205-89-6(Hazardous Substances Data)

Usage

Type of compound

Organosulfur compound

Functional group

Thiourea

Application

Inhibitor of thyroid peroxidase

Medical use

Treatment of hyperthyroidism and Graves' disease

Mechanism of action

Prevents oxidation of iodide to iodine, necessary for thyroid hormone production

Additional uses

Research and as a reagent in organic synthesis

Physical state

White crystalline solid

Stability

Stable under normal conditions

Safety precautions

Handle with care, harmful if ingested or inhaled, can cause skin and eye irritation

Upstream product

• 107-11-9 1-amino-2-propene 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 106-49-0 p-toluidine 
• 57-06-7 N-allyl isothiocyanate 

Downstream Products

• 392246-78-5 C₁₃H₁₄N₂OS 
• 1019333-99-3 C₁₇H₁₈N₂SSe 
• 70446-87-6 5-methyl-2-(4-methylphenylamino)-2-thiazoline 

Relevant articles and documents

Synthesis of new thioureas derivatives and evaluation of their efficacy as proliferation inhibitors in mcf-7 breast cancer cells by using99m tc-mibi radiotracer

Background & Objective: Anti-tumor activity of some thioureas derivatives is well documented in literature and received considerable attention. The present study aims to synthesize and characterize some novel thioureas and carbonylthioureas as anti-tumor

Synthesis, characterization, and antibacterial activity of some thiazoles derived from allyl thioureas

Synthesis of thiazoles was carried out from allyl thioureas using different cyclizing agents such as hydrogen chloride gas and bromine. Synthesized compounds were characterized by IR, 1H and 13C NMR, mass spectrometry, and elemental analysis. The synthesized thiazoles were evaluated for their antibacterial activity against Gram postitive (Lactobacillus bulgaris and Streptococcus mitis) and Gram negative (Yersinia) as well as antifungal activity against Aspergillus niger fungi.