120740-08-1

Basic information

• Product Name: 2-chloro-5-aminomethylthiazole
• Synonyms: 2-chloro-5-aminomethylthiazole;5-Aminomethyl-2-chlorothiazole;(2-chloro-1,3-thiazol-5-yl)MethanaMine;5-ThiazoleMethanaMine, 2-chloro-;2-Chloro-5-thiazoleMethanaMine HCl;2-Chloro-5-Aomethylthiazole
• CAS NO: 120740-08-1
• Molecular Formula: C₄H₅ClN₂S
• Molecular Weight: 148.6139
• Product Categories: Thiazoles;Thiazole
• Mol File: 120740-08-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 121 °C
• Boiling Point: 274.75 °C at 760 mmHg
• Flash Point: 119.965 °C
• Appearance: /
• Density: 1.428 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.68±0.29(Predicted)
• CAS DataBase Reference: 2-chloro-5-aminomethylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-aminomethylthiazole(120740-08-1)
• EPA Substance Registry System: 2-chloro-5-aminomethylthiazole(120740-08-1)

Safety Data

• Hazardous Substances Data: 120740-08-1(Hazardous Substances Data)

Usage

Description

2-chloro-5-aminomethylthiazole is an organic compound with the chemical formula C4H4ClN3S. It is a derivative of thiazole, a heterocyclic compound consisting of a five-membered ring with two nitrogen atoms and one sulfur atom. The presence of a chloro group at the 2-position and an aminomethyl group at the 5-position gives this compound unique chemical properties and potential applications in various fields.

Uses

Used in Pesticide Industry:
2-chloro-5-aminomethylthiazole is used as a metabolite of Thiamethoxam (T344180), a neonicotinoid insecticide. It plays a crucial role in the biological activity and effectiveness of the insecticide in controlling pests, particularly in agricultural settings. The presence of the chloro and aminomethyl groups in the thiazole ring structure contributes to the compound's ability to target and affect the nervous systems of insects, leading to their paralysis and eventual death. This makes it a valuable component in the development and formulation of neonicotinoid-based pesticides for crop protection and other applications.

InChI:InChI=1/C4H5ClN2S/c5-4-7-2-3(1-6)8-4/h2H,1,6H2

Upstream product

• 105827-91-6 α-Cl-β-thiazolyl chloride 
• 1088445-95-7 5-(azidomethyl)-2-chlorothiazole 
• 120740-09-2 N-(2-chloro-5-thiazolylmethyl)phthalimide 
• 1074-82-4 potassium phtalimide 
• 872165-33-8 1,3,5-tris{(2-chloro-1,3-thiazol-5-yl)methyl}-1,3,5-hexahydrotriazine 

Downstream Products

• 1416712-48-5 tert-butyl ((2-chlorothiazol-5-yl)methyl)carbamate 
• 935440-43-0 3-[(2-chlorothiazol-5-yl)methyl]-1-[2-fluoro-4-(trifluoromethylthio)-phenyl]-1-methyl-urea 
• 210880-92-5 clothianidine 

Relevant articles and documents

Design, Synthesis, and Fungicidal Activity of Novel Imidazo[4,5-b]pyridine Derivatives

A series of novel imidazo[4,5-b]pyridine derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by spectroscopic data NMR, MS, and elemental analysis. Bioassay showed that the compounds exhibited potent fungicidal activities against Erysiphe graminis, Puccinia polysora, and so forth. Particularly, 2-chloro-5-((5-methoxy-2-(2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)thiazole (9b) displayed fungicidal potency against P.?polysora. Its EC50 value: 4.00?mg/L is comparable with that of tebuconazole. The structure–activity relationship for the target compounds is discussed.

HEPATITIS B CORE PROTEIN MODULATORS

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound of formula:

Design, synthesis, and particular biological behaviors of chain-opening nitromethylene neonicotinoids with cis configuration

On the basis of the structure of heterocyclic-fused cis configuration derivatives and chain-opening neonicotinoids, two series of novel chain-opening tetrahydropyridine analogues were designed and synthesized. The preliminary bioassay tests were determined on cowpea aphid (Aphis craccivora) and armyworm (Pseudaletia separata Walker). The results showed that some of the target compounds exhibited repellent effects, whereas others showed good insecticidal activities.