1210-35-1Relevant articles and documents
Decomposition of amitriptyline hydrochloride in aqueous solution: identification of decomposition products
Enever,Li Wan Po,Millard,Shotton
, p. 1497 - 1499 (1975)
The decomposition of amitriptyline hydrochloride upon autoclaving in a buffered solution (pH 6.8) was investigated. Three major decomposition products [3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, dibenzosuberone, and 3 (2 oxoethylidene) 1,2:4,5 dibenzocyclohepta 1,4 diene] were detected and identified by chromatographic and spectroscopic techniques. Evidence is presented that the latter two compounds are formed by further oxidation of 3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, and a possible decomposition pathway is outlined.
Excited State Carbon Acids: Base Catalysed Photoketonization of Dibenzosuberenol to Dibenzosuberone via Initial C-H Bond Heterolysis from S1
Wan, Peter,Budac, David,Krogh, Erik
, p. 255 - 257 (1990)
A new photoreaction, the photoketonization of dibenzosuberenol (1) to dibenzosuberone (2) in aqueous solution, is reported, the mechanism of which is believed to involve initial ionization of the C-H proton at the 5-position (in S1), to generate a 5-hydroxy-5-dibenzosuberenyl (9) carbanion intermediate.
Spectrophotometric determination of amitriptyline hcl in pure and pharmaceutical forms
Susmitha,Thirumalachary,Singh, T.Charan,Venkateshwarlu
, p. 2265 - 2270 (2014)
Five spectrophotometric methods for determination of Amitriptyline HCl have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B and C are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue (BTB), Bromophenol blue (BPB) and Bromocresol purple (BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method D depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method E is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with ?max 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precision indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.
Phase-Transfer Permanganate Oxidation of Unfunctionalized Benzylic Positions
Gannon, Sharon M.,Krause, Josef G.
, p. 915 - 917 (1987)
The utility of potassium permanganate in a biphasic medium employing a phase-transfer catalyst is described for the selective oxidations of doubly-benzylic secondary carbons to ketones and doubly-benzylic tertiary carbons to alcohols as well as of singly-benzylic secondary alcohols to ketones.
Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst
Jiang, Hongshuo,Mao, Guijie,Wu, Hongfeng,An, Qi,Zuo, Minghui,Guo, Weihao,Xu, Chunzhao,Sun, Zhizhong,Chu, Wenyi
supporting information, p. 5368 - 5373 (2019/10/11)
An efficient intramolecular radical cyclization reaction via photoredox catalysis was developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a photosensitizer. This strategy could be widely used to synthesize large heterocycles due to the unique reactivity of phosphoranyl radicals formed by a polar/SET crossover between an aromatic carboxylic acid and a phosphine radical cation. Attractive features of this process include generation of an acyl radical by an inexpensive and metal-free photocatalyst, which effectively undergoes a cyclization process.
Method for preparing amitriptyline intermediate by using solid acid catalyst
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Paragraph 0015; 0019; 0023, (2018/07/15)
The invention relates to a method for preparing an amitriptyline intermediate by using a solid acid catalyst. The method for preparing the amitriptyline intermediate by using the solid acid catalyst can effectively solve the problem about green, clean and safe production of the amitriptyline intermediate. The method comprises the steps of adding o-phenethyl benzoic acid and ZSM-5 molecular sievesto a solvent of 5 to 20 times of the total mass of o-phenethyl benzoic acid and ZSM-5 molecular sieves at 0 to 40 DEG C, raising temperature to 60 to 100 DEG C, heating under reflux and stirring for 6to 12 hours, after cooling reaction liquid, filtering under reduced pressure, removing ZSM-5 molecular sieves through filtration, after washing filtrate with water, drying and concentrating to obtaina crude product of 10,11-dihydrodibenzo[a,b]cycloheptene-5-one, and conducting recrystallization with anhydrous ethanol to obtain a pure product of the amitriptyline intermediate. The method for preparing the amitriptyline intermediate can significantly reduce the emission of polluting waste in production, reduce the production cost, and is an innovation in the method for preparing the amitriptyline intermediate.
