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1214348-81-8

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1214348-81-8 Usage

General Description

2-bromo-4-chloro-1-(difluoromethoxy)benzene is a synthetic, halogenated organic compound consisting of a benzene ring as the core structure, with diverse halogen atom attachments. These attachments include a bromine (Br) atom at the second carbon, a chlorine (Cl) atom at the fourth carbon, and a difluoromethoxy group (-OCHF2) at the first carbon. This chemical compound is often used in laboratory settings for different chemical reactions, specifically in organic synthesis due to its reactivity and structural properties. The exact properties (like melting point, boiling point, molecular weight etc.) and hazards of this compound may vary under different conditions. Like many halogenated organic compounds, it needs to be handled with caution due to its potential toxicity and environmental impact.

Check Digit Verification of cas no

The CAS Registry Mumber 1214348-81-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,4,3,4 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1214348-81:
(9*1)+(8*2)+(7*1)+(6*4)+(5*3)+(4*4)+(3*8)+(2*8)+(1*1)=128
128 % 10 = 8
So 1214348-81-8 is a valid CAS Registry Number.
InChI:InChI=1S/C7H4BrClF2O/c8-5-3-4(9)1-2-6(5)12-7(10)11/h1-3,7H

1214348-81-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-4-chloro-1-(difluoromethoxy)benzene

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1214348-81-8 SDS

1214348-81-8Downstream Products

1214348-81-8Relevant articles and documents

Heterocyclic compound and application thereof

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Paragraph 0244-0248, (2021/02/10)

The invention discloses a heterocyclic compound and application thereof. The invention provides a heterocyclic compound shown as a formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. The compound can be used as an FXIa inhibit

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

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Paragraph 2229, (2019/03/30)

The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Zak, Mark,Hanan, Emily J.,Lupardus, Patrick,Brown, David G.,Robinson, Colin,Siu, Michael,Lyssikatos, Joseph P.,Romero, F. Anthony,Zhao, Guiling,Kellar, Terry,Mendonca, Rohan,Ray, Nicholas C.,Goodacre, Simon C.,Crackett, Peter H.,McLean, Neville,Hurley, Christopher A.,Yuen, Po-wai,Cheng, Yun-Xing,Liu, Xiongcai,Liimatta, Marya,Kohli, Pawan Bir,Nonomiya, Jim,Salmon, Gary,Buckley, Gerry,Lloyd, Julia,Gibbons, Paul,Ghilardi, Nico,Kenny, Jane R.,Johnson, Adam

supporting information, p. 1522 - 1531 (2019/04/25)

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule approach to disrupting IL-13 signaling. Herein we demonstrate that JAK1 is likely the isoform most important to IL-13 signaling. Structure-based design was then used to improve the JAK1 potency of a series of previously reported JAK2 inhibitors. The ability to impede IL-13 signaling was thereby significantly improved, with the best compounds exhibiting single digit nM IC50’s in cell-based assays dependent upon IL-13 signaling. Appropriate substitution was further found to influence inhibition of a key off-target, LRRK2. Finally, the most potent compounds were found to be metabolically labile, which makes them ideal scaffolds for further development as topical agents for IL-13 mediated diseases of the lungs and skin (for example asthma and atopic dermatitis, respectively).

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