1215039-66-9

Basic information

• Product Name: ethyl (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate
• CAS NO: 1215039-66-9
• Molecular Weight: 278.221
• Mol File: 1215039-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate(1215039-66-9)
• EPA Substance Registry System: ethyl (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoate(1215039-66-9)

Safety Data

• Hazardous Substances Data: 1215039-66-9(Hazardous Substances Data)

Upstream product

• 116313-85-0 3,4-dihydroxy-5-nitrobenzaldehyde 
• 64-17-5 ethanol 
• 1291066-63-1 (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride 
• 160391-70-8 (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid 

Relevant articles and documents

Efficient approach to pure entacapone and related compounds

A new and efficient process through a new intermediate, (2E)-2-cyano-3-(3,4-dihydroxy-5-nirtrophenyl)prop-2-enoic acid 15, has been described for preparing substantially pure entacapone 1. This new intermediate 15 was prepared by Knoevenagel condensation of 3,4-dihydroxy-5-nitrobenzaldehyde 2 with 2-cyanoacetic acid 14 and was further condensed with diethylamine to get pure entacapone 1. Some of the important process-related impurities of entacapone (17, 18, 19, and 20) were also prepared easily from this intermediate 15. Copyright Taylor & Francis Group, LLC.