1218811-69-8

Basic information

• Product Name: 2-(4-methylphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole
• Synonyms: 2-(4-methylphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole
• CAS NO: 1218811-69-8
• Molecular Weight: 274.322
• Mol File: 1218811-69-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-methylphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(1218811-69-8)
• EPA Substance Registry System: 2-(4-methylphenyl)-5-[(4-methylphenyl)ethynyl]-1,3,4-oxadiazole(1218811-69-8)

Safety Data

• Hazardous Substances Data: 1218811-69-8(Hazardous Substances Data)

Upstream product

• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 766-97-2 4-n-methylphenylacetylene 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 31638-66-1 (p-tolylethynyl)copper 
• 3619-22-5 p-toluic hydrazide 
• 104-87-0 4-methyl-benzaldehyde 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 

Relevant articles and documents

Palladium-Catalyzed Decarboxylative Cross-Coupling of 1,3,4-Oxa-diazoles with Alkynoic Acids: A Simple Route for the Preparation of 2-Alkynylated 1,3,4-Oxadiazoles

For the first time 2-alk-1-ynyl-5-(het)aryl-1,3,4-oxadiazole derivatives have been synthesized by the decarboxylative cross-coupling of alk-2-ynoic acids with 2-(het)aryl-1,3,4-oxadiazoles, employing palladium(II) chloride as the catalyst and silver(I) oxide as an oxidant with 1,3-bis(diphenylphosphanyl)propane as a ligand. Products were formed in high yields with no byproduct.

Synthesis of 2-alkynyl 1,3,4-oxadiazoles by palladium-catalyzed cross- coupling reaction 1

Several 2-alkynyl 1,3,4-oxadiazoles have been synthesized efficiently by employing palladium-catalyzed cross-coupling under Sonogashira reaction conditions. This reaction has been applied for the first time for the preparation of oxadiazole derivatives. T

Copper-mediated direct cross-coupling of 1,3,4-oxadiazoles and oxazoles with terminal alkynes

Copper-mediated direct cross-coupling of 1, 3, 4-oxadiazoles and oxazoles with terminal alkynes has been reported. The transition-metal-mediated direct functionalization reactions of C-H bonds have attracted significant interest in modern organic chemistry. The mixture was heated at 120°C, and the slow addition of 1 hour of a solution of phenylacetylene in DMAc (1.0 mL) as then started. The cross-coupling using CuCl2/DMEDA system. Thus, the desired 2-alkynyl-5-aryloxazoles were obtained by performing the reaction in a higher ratio at 150°C with DMSO as solvent. The oxadiazoles with various substituents at the 2-position were also available for use. 4- Methyl-, 4-methoxy-, 4-trifluoromethyl-, and 4-chloro- phenyl-1, 3, 4-oxadiazoles coupled with 4-MeC5H4, to furnish compound.