1218947-78-4

Basic information

• Product Name: C₁₈H₁₉NO₅S
• Synonyms: C₁₈H₁₉NO₅S
• CAS NO: 1218947-78-4
• Molecular Weight: 361.419
• Mol File: 1218947-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₉NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₉NO₅S(1218947-78-4)
• EPA Substance Registry System: C₁₈H₁₉NO₅S(1218947-78-4)

Safety Data

• Hazardous Substances Data: 1218947-78-4(Hazardous Substances Data)

Upstream product

• 2982-55-0 1-benzyloxy-4-(2-nitroethenyl)benzene 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 1218947-82-0 2-(4'-benzyloxyphenyl)thiomorpholin-5-one 

Relevant articles and documents

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors

2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight into the binding mode of these inhibitors and rationalized their different potencies. Making the phenylethylamine scaffold rigid by fixing the amine chain in an extended six-membered ring conformation increased MAO-B (but not MAO-A) inhibitory activity relative to the more flexible α-methylated derivative. The presence of a basic nitrogen atom is not a prerequisite in either MAO-A or MAO-B. The best Ki values were in the 10-8 M range, with selectivities towards human MAO-B exceeding 2000-fold.