121936-50-3Relevant articles and documents
Taming of a superbase for selective phenol desilylation and natural product isolation
Trader, Darci J.,Carlson, Erin E.
, p. 7349 - 7355 (2013/08/23)
Hydroxyl moieties are highly prevalent in natural products. We previously reported a chemoselective strategy for enrichment of hydroxyl-functionalized molecules by formation of a silyl ether bond to a resin. To generate smaller pools of molecules for analysis, we developed cleavage conditions to promote stepwise release of phenolic silyl ethers followed by aliphatic silyl ethers with a "tamed" version of the superbase 1,1,3,3-tetramethylguanadine. We demonstrate this as a general strategy for selective deprotection of phenolic silyl ethers under neutral conditions at room temperature.
Syntheses of the Saturated Analogues of 4-Nitrophenol and 4-Nitroaniline
Janda, Kim D.,Ashley, Jon A.
, p. 1073 - 1082 (2007/10/02)
Two syntheses for 4-nitrocyclohexanol and 4-nitrocyclohexanamine are presented.Both conveniently start from commercially available 4-aminocyclohexanol.
