122030-65-3Relevant articles and documents
Total synthesis of conolidine and apparicine
Takanashi, Noriyuki,Suzuki, Kenta,Kitajima, Mariko,Takayama, Hiromitsu
, p. 375 - 378 (2016)
A total synthesis of indole alkaloids, (±)-conolidine and (±)-apparicine, was accomplished via a gold(I)-catalyzed 6-exo-dig cyclization to construct a piperidine ring bearing an exocyclic (E)-ethylidene appendage.
Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms
Bunders, Cynthia,Cavanagh, John,Melander, Christian
scheme or table, p. 5476 - 5481 (2011/09/12)
Anti-biofilm agents have been developed based upon the flustramine family of alkaloids isolated from Flustra foliacea. A Garg interrupted Fischer indolization reaction was employed to access a core pyrroloindoline scaffold that was subsequently employed t
Ring expansion of lactones and lactams via propiolate 1-carbon intercalation
Grant, Tina N.,Benson, Chantel L.,West
supporting information; experimental part, p. 3985 - 3988 (2009/05/30)
(Chemical Equation Presented) Readily available five- and six-membered lactones and N-sulfonyllactams undergo efficient addition of t-butyl propiolate, and the resulting adducts undergo cycloisomerization to six- and seven-membered cyclic ethers or amines in the presence of pyridinium acetate. The ring expansion process occurs in generally good yields and is proposed to involve a nucleophilic catalysis mechanism.
