1222172-50-0

Basic information

• Product Name: Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate
• Synonyms: Benzoic acid, 5-(acetylamino)-2-[(2-cyanoethenyl)amino]-4-ethoxy-, methyl ester
• CAS NO: 1222172-50-0
• Molecular Formula: C15H17N3O4
• Molecular Weight: 303.318
• Mol File: 1222172-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate(1222172-50-0)
• EPA Substance Registry System: Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate(1222172-50-0)

Safety Data

• Hazardous Substances Data: 1222172-50-0(Hazardous Substances Data)

Upstream product

• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 5817-82-3 3-(morpholin-4-yl)acrylonitrile 
• 2407-68-3 3-dimethylaminoacrylonitrile 
• 1222172-49-7 methyl 5-acetamido-2-amino-4-ethoxybenzoate 
• 1201080-20-7 methyl 3-acetamido-4-ethoxybenzoate 
• 1201080-23-0 methyl 5-acetamido-4-ethoxy-2-nitrobenzoate 
• 6162-76-1 cyanoacetaldehyde 
• 2032-34-0 3,3-bis(ethyloxy)propanenitrile 

Downstream Products

• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 
• 848133-75-5 3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline 
• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 

Relevant articles and documents

A new and improved process for N -(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide

A new and improved synthetic route to N-(4-chloro-3-cyano-7-ethoxyquinolin- 6-yl)acetamide (1) is described on a kilogram scale. The key step is the basic cyclization of o-[(2-cyanovinyl)amino]benzoate (14) in tBuONa/ tBuOH system to give the 3-cyano-4-hydroxyquinoline (7). The final product 1 is obtained with 49% overall yield (seven steps) and 98.9% purity (HPLC), which makes it a cost-effective and commercially friendly process for scale-up operations.