1222172-52-2

Basic information

• Product Name: ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate
• Synonyms: ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate
• CAS NO: 1222172-52-2
• Molecular Weight: 317.345
• Mol File: 1222172-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate(1222172-52-2)
• EPA Substance Registry System: ethyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate(1222172-52-2)

Safety Data

• Hazardous Substances Data: 1222172-52-2(Hazardous Substances Data)

Upstream product

• 2032-34-0 3,3-bis(ethyloxy)propanenitrile 
• 1222172-51-1 ethyl 5-acetamido-2-amino-4-ethoxybenzoate 
• 26118-19-4 [1,3]dioxolan-2-yl-acetonitrile 
• 2407-68-3 3-dimethylaminoacrylonitrile 

Downstream Products

• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 
• 848133-75-5 3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline 

Relevant articles and documents

PREPARATION METHODS OF 6-SUBSTITUTED AMINO-3-CYANOQUINOLINE COMPOUNDS AND THE INTERMEDIATES THEREOF

The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.