122620-80-8Relevant articles and documents
Total Synthesis of the Diterpenoid (+)-Harringtonolide
Zhang, Hai -Jun,Hu, Lin,Ma, Zhiqiang,Li, Ruining,Zhang, Zhen,Tao, Cheng,Cheng, Bin,Li, Yun,Wang, Huifei,Zhai, Hongbin
, p. 11638 - 11641 (2016)
Described herein is the first asymmetric total synthesis of (+)-harringtonolide, a natural diterpenoid with an unusual tropone imbedded in a cagelike framework. The key transformations include an intramolecular Diels–Alder reaction and a rhodium-complex-c
COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT
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Page/Page column 53, (2019/12/15)
The present invention features novel peripherally-restricted isoguvacine analogs with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism S
Achieving Regio- and Enantioselectivity of P450-Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure-Guided Directed Evolution
Agudo, Ruben,Roiban, Gheorghe-Doru,Reetz, Manfred T.
body text, p. 1465 - 1473 (2012/09/08)
Directed evolution of the monooxygenase P450-BM3 utilizing iterative saturation mutagenesis at and near the binding site enables a high degree of both regio- and enantioselectivity in the oxidative hydroxylation of cyclohexene-1-carboxylic acid methyl est
