1226460-46-3

Basic information

• Product Name: 5-(3-phenylfuroxan-4-yloxy)pentan-1-ol
• Synonyms: 5-(3-phenylfuroxan-4-yloxy)pentan-1-ol
• CAS NO: 1226460-46-3
• Molecular Weight: 264.281
• Mol File: 1226460-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3-phenylfuroxan-4-yloxy)pentan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-phenylfuroxan-4-yloxy)pentan-1-ol(1226460-46-3)
• EPA Substance Registry System: 5-(3-phenylfuroxan-4-yloxy)pentan-1-ol(1226460-46-3)

Safety Data

• Hazardous Substances Data: 1226460-46-3(Hazardous Substances Data)

Upstream product

• 111-29-5 1 ,5-pentanediol 
• 76016-71-2 3-phenyl-4-benzenesulfonylfuroxan 

Downstream Products

• 1226460-47-4 5-(3-phenylfuroxan-4-yloxy)pentanoic acid 

Relevant articles and documents

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs)

A new series of bisphosphonates bearing either the nitrogen-containing NO-donor furoxan (1,2,5-oxadiazole 2-oxide) system or the related furazan (1,2,5-oxadiazole) in lateral chain has been developed. pKa values and affinity for hydroxyapatite were determined for all the compounds. The products were able to inhibit osteoclastogenesis on RAW 246.7 cells at 10 μM concentration. The most active compounds were further assayed on human PBMC cells and on rat microsomes. Unlike most nitrogen-containing bisphosphonates which target farnesyl pyrophosphate synthase, experimental and theoretical investigations suggest that the activity of our derivatives may be related to different mechanisms. The furoxan derivatives were also tested for their ability to relax rat aorta strips in view of their potential NO-dependent vasodilator properties.