1226527-27-0

Basic information

• Product Name: 2-(5-chloro-benzothiazole-2-sulfonyl)-2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone
• Synonyms: 2-(5-chloro-benzothiazole-2-sulfonyl)-2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone
• CAS NO: 1226527-27-0
• Molecular Weight: 596.823
• Mol File: 1226527-27-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-chloro-benzothiazole-2-sulfonyl)-2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-chloro-benzothiazole-2-sulfonyl)-2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone(1226527-27-0)
• EPA Substance Registry System: 2-(5-chloro-benzothiazole-2-sulfonyl)-2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone(1226527-27-0)

Safety Data

• Hazardous Substances Data: 1226527-27-0(Hazardous Substances Data)

Upstream product

• 1226526-69-7 2-(5-chlorobenzothiazole-2-sulfonyl)-1-phenylethan-1-one 
• 400-91-9 1-bromo-3-fluoro-4,6-dinitrobenzene 

Downstream Products

• 1226527-68-9 1-bromo-2,4-dinitro-5-(phenylethynyl)benzene 
• 1226527-94-1 2-(5-bromo-2,4-dinitro-phenyl)-1-phenyl-ethanone 

Relevant articles and documents

Transition-metal-free formal sonogashira coupling and α-carbonyl arylation reactions

Transition-metal-free formal Sonogashira coupling and α-carbonyl arylation reactions have been developed. These transformations are based on the nucleophilic aromatic substitution (SNAr) of β-carbonyl sulfones to electron-deficient aryl fluorides, producing a key intermediate that, depending on the reaction conditions, gives the aromatic alkynes or α-aryl carbonyl compounds. The development of these reactions is presented and, based on investigations under basic and acidic conditions, mechanisms have been proposed. To develop the formal disclosed that expands the reaction concept. The scope of these reactions is demonstrated for the synthesis of Sonogashira and α-carbonyl arylated products from a range of electron-deficient aryl fluorides with a variety of functional groups and aryl-, heteroaryl-, alkyl-, and alkoxy-substituted sulfone nucleophiles. These transition-metal-free reactions complement the metal-catalyzed versions in terms of substitution patterns, simplicity, and reaction conditions.