1228017-72-8

Basic information

• Product Name: methyl 2-azido-5-fluorobenzoate
• Synonyms: methyl 2-azido-5-fluorobenzoate
• CAS NO: 1228017-72-8
• Molecular Weight: 195.153
• Mol File: 1228017-72-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-azido-5-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-azido-5-fluorobenzoate(1228017-72-8)
• EPA Substance Registry System: methyl 2-azido-5-fluorobenzoate(1228017-72-8)

Safety Data

• Hazardous Substances Data: 1228017-72-8(Hazardous Substances Data)

Upstream product

• 319-24-4 2-amino-5-fluoro-benzoic acid methyl ester 

Downstream Products

• 1227262-40-9 C₁₅H₉FN₄O₃S 

Relevant articles and documents

Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents

Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.