1228269-76-8

Basic information

• Product Name: (E)-5-bromo-2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)benzamide
• Synonyms: (E)-5-bromo-2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)benzamide
• CAS NO: 1228269-76-8
• Molecular Weight: 503.134
• Mol File: 1228269-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-5-bromo-2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-bromo-2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)benzamide(1228269-76-8)
• EPA Substance Registry System: (E)-5-bromo-2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)benzamide(1228269-76-8)

Safety Data

• Hazardous Substances Data: 1228269-76-8(Hazardous Substances Data)

Upstream product

• 1761-62-2 5-iodosalicyclaldehyde 
• 1228269-90-6 C₁₀H₁₃BrN₂O₂ 

Relevant articles and documents

Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics

We described here the design, synthesis, molecular modeling, and biological evaluation of a series of peptide and Schiff bases (PSB) small molecules, inhibitors of Escherichia coli β-Ketoacyl-acyl carrier protein synthase III (ecKAS III). The initial lead compound was reported by us previously, we continued to carry out structure-activity relationship studies and optimize the lead structure to potent inhibitors in this research. The results demonstrated that both N-(2-(3,5-dichloro-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide (1f) and 2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)-4-methylbenzamide (3e) posses good ecKAS III inhibitory activity and well binding affinities by bonding Gly152/Gly209 of ecKAS III and fit into the mouth of the substrate tunnel, and can be as potential antibiotics agent, displaying minimal inhibitory concentration values in the range 0.20-3.13 μg/mL and 0.39-3.13 μg/mL against various bacteria.