1229005-35-9

Basic information

• Product Name: Tatariid A
• Synonyms: Tatariid A;Tatarinoid A;(2R)-2-Hydroxy-1-(2,4,5-trimethoxyphenyl)-1-propanone
• CAS NO: 1229005-35-9
• Molecular Formula: C₁₂H₁₆O₅
• Molecular Weight: 240.25244
• Mol File: 1229005-35-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 384.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.158±0.06 g/cm3(Predicted)
• PKA: 13.02±0.20(Predicted)
• CAS DataBase Reference: Tatariid A(CAS DataBase Reference)
• NIST Chemistry Reference: Tatariid A(1229005-35-9)
• EPA Substance Registry System: Tatariid A(1229005-35-9)

Safety Data

• Hazardous Substances Data: 1229005-35-9(Hazardous Substances Data)

Usage

General Description

Tatariid A is a natural product derived from the roots of the plant Tatarian aster. It is a diterpenoid compound with a complex chemical structure, containing multiple rings and functional groups. Tatariid A has been found to possess various biological activities, including anti-inflammatory, anti-tumor, and anti-fungal properties. It has also been shown to inhibit the growth of certain cancer cell lines in laboratory studies. Research into the potential medicinal applications of Tatariid A is ongoing, as scientists continue to investigate its mechanisms of action and potential therapeutic uses.

Upstream product

• 1422453-73-3 (R)-2-(tert-butyldimethylsilyloxy)-1-(2,4,5-trimethoxyphenyl)propan-1-one 
• 29652-82-2 1-(2,4,5-Trimethoxyphenyl)propan-1-ol 
• 3904-18-5 isoacoramone 
• 22973-79-1 2-(2,4,5-trimethoxyphenyl)acetaldehyde 

Relevant articles and documents

Asymmetric Oxidation of Enol Derivatives to α-Alkoxy Carbonyls Using Iminium Salt Catalysts: A Synthetic and Computational Study

We report herein the first examples of asymmetric oxidation of enol ether and ester substrates using iminium salt organocatalysis, affording moderate to excellent enantioselectivities of up to 98% ee for tetralone-derived substrates in the α-hydroxyketone products. A comprehensive density functional theory study was undertaken to interpret the competing diastereoisomeric transition states in this example in order to identify the origins of enantioselectivity. The calculations, performed at the B3LYP/6-31G(D) level of theory, gave good agreement with the experimental results, in terms of the magnitude of the effects under the specified reaction conditions, and in terms of the preferential formation of the (R)-enantiomer. Just one of the 30 characterized transition states dominates the enantioselectivity, which is attributed to the adoption of an orientation relative to stereochemical features of the chiral controlling element that combines a CH interaction between a CH2 group in the substrate and one of the aromatic rings of the biaryl section of the chiral auxiliary with a good alignment of the acetoxy group with the other biaryl ring, and places the smallest substituent on the alkene (a hydrogen atom) in the most sterically hindered position.