123-09-1Relevant articles and documents
Chemistry of Dioxiranes. 6. Electronic Effects in the Oxidation of Sulfides and Sulfoxides by Dimethyldioxirane
Murray, Robert W.,Jeyaraman, Ramasubbu,Pillay, M. Krishna
, p. 746 - 748 (1987)
Dimethyldioxirane (1) oxidizes a series of aryl methyl sulfides to the corresponding sulfoxides.In a separate series of reactions the sulfoxides were oxidized by 1 to the corresponding sulfones.The relative rates of oxidation in both series were treated with the Hammett ρ? relationship.The oxidations were found to be electrophilic in character with ρ values for the sulfide and sulfoxide oxidations equal to -0.77 and -0.76, respectively.
Alkyl Radical Substitution on Disulfide in the Presence of Cobalt(II) Complexes
Tada, Masaru,Sugano, Kiyohiko,Yoshihara, Takao
, p. 2969 - 2974 (1995)
Photolysis of methyl(L)cobaloxime (L=trans ligand) (1) or methyl(L)-O,O'-bis(difluoroboryl)cobaloxime (2) in the presence of bis(4-chlorophenyl) disulfide gave 4-chlorophenyl methyl sulfide together with 4-chlorophenylthio(L)cobaloxime (5) or 4-chlorophenylthio(L)-O,O'-bis(difluoroboryl)cobaloxime (6).Similar photolysis in the presence of 2,2,6,6-tetramethyl-1-piperidyloxyl (TEMPO) gives 1-methoxy-2,2,6,6-tetramethylpiperidine.The reactivity of the cobaloximes 1 and 2 to the disulfide and TEMPO increases when the cobaloximes have a trans ligand (L) of larger steric requirement and low pka, or when the equatorial ligand is an electronegative O-(difluoroboryl)dimethylglyoxime.Two probable mechanisms are proposed for the reaction.The first is a direct radical substitution on the disulfide with a methyl radical, and the second involves the initial interaction between the disulfide and the (L)cobaloxime radical to afford arylthio(L)cobaloxime (5 or 6) and an arylthio radical. the latter radical reacts with methyl(L)cobaloxime to give aryl methyl sulfide.
PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF
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Paragraph 0394; 0395, (2021/04/10)
The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.
Synthesis of Aryl Methyl Sulfides from Arysulfonyl Chlorides with Dimethyl Carbonate as the Solvent and C1 Source
Miao, Ren-Guan,Qi, Xinxin,Wu, Xiao-Feng
supporting information, p. 5219 - 5221 (2021/10/19)
A new procedure for the synthesis of aryl methyl sulfides from dimethyl carbonate (DMC) and arylsulfonyl chlorides has been achieved. In this strategy, DMC plays a dual role as both, C1 building block and green solvent. Arylsulfonyl chlorides served as the sulfur precursors, and a variety of aryl methyl sulfides were obtained in moderate to excellent yields with good functional group tolerance. Additionally, alkylsulfonyl chloride and dibenzyl carbonate are proven to be suitable substrates as well.