1232515-39-7

Basic information

• Product Name: C₃₅H₄₃N₅O₇
• CAS NO: 1232515-39-7
• Molecular Weight: 645.756
• Mol File: 1232515-39-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₄₃N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₄₃N₅O₇(1232515-39-7)
• EPA Substance Registry System: C₃₅H₄₃N₅O₇(1232515-39-7)

Safety Data

• Hazardous Substances Data: 1232515-39-7(Hazardous Substances Data)

Upstream product

• 35661-40-6 N-Fmoc L-Phe 
• 71989-31-6 (R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 
• 146549-21-5 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid 
• 143824-78-6 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1232515-49-9 C₃₅H₄₁N₅O₆ 

Relevant articles and documents

Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222

In the course of our ongoing efforts to discover new and more effective HDAC inhibitors useful for the development of promising anticancer candidates, we have recently undertaken a molecular modelling study on a small collection of FR235222 analogues, synthesized by us in the frame of a structure-activity relationship investigation, made in order to identify the key structural elements essential for the activity. Progress made in structure elucidation of HDAC active site, together with accurate docking calculations, provided new structural insights useful for a further refinement of the tetrapeptide scaffold which should assure an optimal interaction between the synthetic ligands and the biological target. Following the computer aided suggestions we synthesized six new cyclotetrapeptide analogues of the lead compound (3-8), bearing a carboxylic or an hydroxamic acid functionality as Zn binding moiety. Herein we describe their synthesis and their inhibition activity on different HDAC isoforms.