1233482-00-2Relevant articles and documents
Stereoselective synthesis of a dioxa-bicyclo[3.2.1]octane SGLT2 inhibitor
Mascitti, Vincent,Preville, Cathy
, p. 2940 - 2943 (2010)
A promising class of SGLT2 inhibitors bearing a unique dioxa-bicyclo[3.2.1] octane motif was recently disclosed. An improved stereoselective synthesis providing efficient access to one of the most potent and selective compounds from this class is reported. A one-pot deprotection/cyclization was used as the key step to form the dioxa-bicyclo[3.2.1]octane motif with full control of stereochemistry. Using an appropriately substituted aryl group, the route enables the synthesis of any given compound from the class.
