1234-27-1

Basic information

• Product Name: 4-{[(4-carboxyphenyl)carbamoyl]amino}benzoic acid
• Synonyms: benzoic acid, 4,4'-(carbonyldiimino)bis-
• CAS NO: 1234-27-1
• Molecular Formula: C₁₅H₁₂N₂O₅
• Molecular Weight: 300.2662
• Mol File: 1234-27-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 458.7°C at 760 mmHg
• Flash Point: 231.2°C
• Density: 1.54g/cm³
• Vapor Pressure: 3.3E-09mmHg at 25°C
• Refractive Index: 1.744
• CAS DataBase Reference: 4-{[(4-carboxyphenyl)carbamoyl]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(4-carboxyphenyl)carbamoyl]amino}benzoic acid(1234-27-1)
• EPA Substance Registry System: 4-{[(4-carboxyphenyl)carbamoyl]amino}benzoic acid(1234-27-1)

Safety Data

• Hazardous Substances Data: 1234-27-1(Hazardous Substances Data)

Usage

Description

4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid is a chemical compound with the molecular formula C16H13N3O5. It is a derivative of benzoic acid and contains a carboxylic acid group, an amino group, and a carbamoyl group. 4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid is known for its potential as an anti-inflammatory and analgesic agent, and it has been studied for its potential role in treating various medical conditions, including cancer and neurological disorders. The chemical structure of 4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid allows for diverse interactions with biological systems, making it an important target for further investigation and potential therapeutic applications.

Uses

Used in Pharmaceutical Research and Drug Development:
4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid is used as a research compound for its potential as an anti-inflammatory and analgesic agent. Its unique chemical structure enables it to interact with biological systems in various ways, which makes it a promising candidate for the development of new drugs to treat a range of medical conditions.
Used in Medical Treatments:
In the medical field, 4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid is being studied for its potential role in treating various conditions such as cancer and neurological disorders. Its ability to interact with biological systems suggests that it could be a valuable component in the development of therapies for these and other diseases.
Used in Cancer Treatment Research:
4-[(4-carboxyphenyl)carbamoyl]aminobenzoic acid is used as a subject of research in cancer treatment. Its potential role in this area is being explored due to its interactions with biological systems, which could lead to the development of new cancer therapies.
Used in Neurological Disorder Research:
Similarly, this compound is also being investigated for its potential application in the treatment of neurological disorders. The diverse interactions it can have with biological systems make it a candidate worth studying for the development of treatments that could improve the lives of those affected by such conditions.

Upstream product

• 110-86-1 pyridine 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 150-13-0 4-amino-benzoic acid 
• 57-13-6 urea 
• 598-50-5 N-Methylurea 
• 1070978-92-5 4,4'-ureylene-di-(tert-butylbenzoate) 
• 94-09-7 p-aminoethylbenzoate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 18144-47-3 tert-butyl 4-aminobenzoate 
• 62-23-7 4-nitro-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 56050-99-8 dimethyl 4,4'-(carbonylbis(azanediyl))dibenzoate 
• 3582-05-6 trifluoromethyl trifluoromethanesulfonate 

Downstream Products

• 1070977-85-3 1,3-bis(4-(4-(3-(pyrrolidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea 
• 1070977-92-2 1,3-bis(4-(3-(3-(pyrrolidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea 
• 1070977-90-0 1,3-bis(4-(3-(2-(pyrrolidin-1-yl)acetamido)phenylcarbamoyl)phenyl)urea 
• 1070977-83-1 1,3-bis(4-(4-(2-(pyrrolidin-1-yl)acetamido)phenylcarbamoyl)phenyl)urea 
• 1070977-87-5 1,3-bis(4-(4-(4-(pyrrolidin-1-yl)butanamido)phenylcarbamoyl)phenyl)urea 
• 1070977-95-5 1,3-bis(4-(3-(4-(pyrrolidin-1-yl)butanamido)phenylcarbamoyl)phenyl)urea 

Relevant articles and documents

Urea-based flexible dicarboxylate linkers for three-dimensional metal-organic frameworks

The metal-organic frameworks (MOFs) 3D-[Mn2(L1)2(DMF)]·2DMF (1), 3D-[Cd2(L2)2(DMF)3] (3), [Zn2(L2)2(DMF)3] (4) and 3D-[Mn2(L2)2(DMF)3] (5) are the first examples of three-dimensional metal-organic networks constructed from a single ditopic dicarboxylate linker (i.e., without bridging co-ligands) with an urea group in the linker axis (L12? = 4,4′-(carbonylbis(azanediyl))dibenzoate; L22? = 4,4′-(carbonylbis(azanediyl))bis(3-methylbenzoate), DMF = dimethylformamide). From Cd2+and L12? a 1D coordination polymer 1D-[Cd(L1)(DMF)3] (2) is formed. The urea group is engaged in hydrogen bonding with the C(4)[R12(6)] motif to an oxygen atom of a DMF solvent (in 1) or a metal-coordinated carboxylate group (in 3–5). Network 1 has infinite channels with parallelepiped cross sections and 30% solvent-filled volume. The 3 D frameworks 3–5 are of diamond (6,6), dia topology with a single framework having large voids with 17.6 ? and 19.7 ? nodal separation. Thus, four symmetry-related nets interpenetrate, organized via H-bonds in the C(4)[R12(6)] motif, still leaving about 50% solvent-filled void volume in the fourfold interpenetrated structure.

Concise and Additive-Free Click Reactions between Amines and CF3SO3CF3

Trifluoromethyl trifluoromethanesulfonate has proved to be an excellent reservoir of difluorophosgene and a promising click ligation for amines in the preparation of urea derivatives, heterocycles, and carbamoyl fluorides under metal- and additive-free conditions. The reactions are rapid, efficient, selective, and versatile, and can be performed in benign solvents, giving products in excellent yields with minimal efforts for purification. The characteristics of the reactions meet the requirements of a click reaction. The use of trifluoromethyl trifluoromethanesulfonate as a click reagent is advantageous over other “CO” sources (e.g., TsOCF3, PhCO2CF3, CsOCF3, AgOCF3, and triphosgene) because this reagent is readily accessible; easy to scale up; and highly reactive, even under metal- and additive-free conditions. It is anticipated that CF3SO3CF3 will be increasingly as important as SO2F2 as a click agent in future drug design and development.

Urea-containing metal-organic frameworks as heterogeneous organocatalysts

Two novel pillared metal-organic frameworks (MOFs) containing a urea-functional group are introduced. Herein, the urea functional group was incorporated into the MOF backbone by preparing a urea-ditopic ligand. These frameworks (TMU-18 and TMU-19) were fabricated using the synthesized urea-containing ligand, 4,4′-bipyridine (bipy) and 1,2-bis(4-pyridyl)ethane (bpe), and using zinc nitrate as the metal source. Subsequently, TMU-18 and TMU-19 were characterized by X-ray diffraction, IR spectroscopy, elemental analysis, scanning electron microscopy (SEM) and thermogravimetric analysis. Furthermore, their potential efficiency as organocatalysts was evaluated in the regioselective methanolysis of epoxides.