1234321-81-3Relevant articles and documents
Recycling method of acetyl Meldrum's acid derivative degradation waste
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Paragraph 0056-0061; 0065-0067, (2021/07/01)
The invention provides a recycling method of acetyl Meldrum's acid derivative degradation waste, and belongs to the technical field of resource reutilization. According to the method disclosed by the invention, acetyl Meldrum's acid derivative degradation waste is subjected to preheating treatment, alcoholysis reaction, ammonolysis reaction, acetylation reaction and purification treatment, the main components in theacetyl Meldrum's acid derivative degradation waste are converted, and a recovery product is finally obtained and can be used as an important intermediate in a sitagliptin production process, so that waste resource reutilization in the production process of the sitagliptin bulk drug is realized, economic loss caused by degradation of the acetyl Meldrum's acid derivative in the production process of the sitagliptin bulk drug is reduced, the problem of environmental pollution caused by degradation of the acetyl Meldrum's acid derivative in the production process of the sitagliptin bulk drug is eliminated, and the sustainable development of a sitagliptin raw material medicine green pharmaceutical process is promoted.
Highly efficient and facile synthesis of β-enaminones catalyzed by diphenylammonium triflate
Zhao, Ting-Ting,Song, Jiang-Long,Hong, Feng-Qing,Xia, Jian-Sheng,Li, Jian-Jun
, p. 2857 - 2868 (2019/08/21)
Abstract: The catalytic performance of diphenylammonium triflates as an organocatalyst in the synthesis of β-enaminones from various substituted β-diketones and amides (or amines) were evaluated. A wide range of β-enaminones were efficiently synthesized in good to excellent yields under mild reaction conditions. Applying diphenylammonium triflate (DPAT) as catalyst makes this protocol cost-effective, low corrosive and easy to handle. Graphic abstract: [Figure not available: see fulltext.].