123485-25-6

Basic information

• Product Name: (1R,2R)-1,2-diacetoxy-1-phenylpropane
• Synonyms: (1R,2R)-1,2-diacetoxy-1-phenylpropane
• CAS NO: 123485-25-6
• Molecular Weight: 236.268
• Mol File: 123485-25-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (1R,2R)-1,2-diacetoxy-1-phenylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-1,2-diacetoxy-1-phenylpropane(123485-25-6)
• EPA Substance Registry System: (1R,2R)-1,2-diacetoxy-1-phenylpropane(123485-25-6)

Safety Data

• Hazardous Substances Data: 123485-25-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 1075-04-3 1-phenylpropane-1,2-diol 
• 108-22-5 Isopropenyl acetate 
• 88196-06-9 syn-1-phenylpropane-1,2-diol 
• 1798-60-3 (R)-1-hydroxy-1-phenyl-2-propanone 
• 4962-46-3 (±)-erythro-2-bromo-1-phenylpropyl acetate 
• 563-63-3 silver(I) acetate 
• 873-66-5 1-propenylbenzene 
• 64-19-7 acetic acid 
• 4962-46-3 (1RS,2RS)-1-acetoxy-2-bromo-1-phenyl-propane 
• 766-90-5 cis-1-phenyl-1-propylene 
• 79-21-0 peracetic acid 
• 40421-52-1 (1RS,2SR)-1-phenylpropane-1,2-diol 
• 127-08-2 potassium acetate 

Downstream Products

• 40421-51-0 (1R,2R)-1-phenylpropane-1,2-diol 
• 40421-52-1 (1RS,2SR)-1-phenylpropane-1,2-diol 

Relevant articles and documents

B2pin2-Mediated Palladium-Catalyzed Diacetoxylation of Aryl Alkenes with O2 as Oxygen Source and Sole Oxidant

A novel palladium-catalyzed alkene diacetoxylation with dioxygen (O2) as both the sole oxidant and oxygen source is developed, which was identified by 18O-isotope labeling studies. Control experiments suggested that bis(pinacolato)diboron (B2pin2) played a dominant intermediary role in the formation of a C-O bond. This method performed good functional group tolerance with moderate to excellent yields, which could be successfully applied to the late-stage modification of natural products. Furthermore, an atmospheric pressure of dioxygen enhances the practicability of the protocol.

Vicinal Difunctionalization of Alkenes under Iodine(III) Catalysis involving Lewis Base Adducts

The influence of a 2-pyridinyl substituent on the catalytic performance of aryl iodides as catalyst in iodine(III) chemistry was explored. An efficient Lewis base adduct between the pyridine nitrogen and the electrophilic iodine(III) center was identified and confirmed by X-ray analysis. This arrangement was shown to generate a kinetically competent superior catalyst structure for the catalytic dioxygenation of alkenes. It introduces the concept of Lewis base adduct formation as a kinetic factor in iodine(I/III) catalysis. (Figure presented.).

Synthesis of Optically Active 1-Phenyl-1,2-propanediol by Use of Baker's Yeast

Reduction of 1-phenyl-1,2-propanedione with baker's yeast afforded (1R,2S)-1-phenyl-1,2-propanediol in high chemical and optical yield. (1R,2S)-, (1R,2R)- and (1S,2S)-1,2-propanediols were also prepared via (1R)- or (2S)-α-ketols, which were obtained as intermediates of the above reaction.