1239316-25-6Relevant articles and documents
A multi-task palladium catalyst involved in heck-reduction-cyclization sequences for the preparation of 4-benzyl-1,2-dihydroisoquinolin-3-ones: An unusual homogeneous-heterogeneous sustainable approach
Laudien, Julia,Fouquet, Eric,Zakri, Cécile,Felpin, Fran?ois-Xavier
experimental part, p. 1539 - 1543 (2010/08/22)
A mixed homogeneous-heterogeneous catalysis that exploits a multi-task palladium catalyst has been developed for one-pot sequential Heck-reduction-cyclization (HRC) reactions leading to novel 4-benzyl-1,2- dihydroisoquinolin-3-ones. The HRC sequence requires mild conditions and allows the separation of the palladium residues under the form of an in situ generated Pd(0)/C catalyst by simple filtration. The homemade and recovered catalyst can be efficiently reused for Suzuki-Miyaura reactions and reductive processes making it useful for sustainable chemistry. Georg Thieme Verlag Stuttgart New York.