124401-05-4

Basic information

• Product Name: 3-(thiophen-2-yl)-1,2-benzisothiazole 1,1-dioxide
• Synonyms: 3-(thiophen-2-yl)-1,2-benzisothiazole 1,1-dioxide
• CAS NO: 124401-05-4
• Molecular Weight: 311.284
• Mol File: 124401-05-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(thiophen-2-yl)-1,2-benzisothiazole 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(thiophen-2-yl)-1,2-benzisothiazole 1,1-dioxide(124401-05-4)
• EPA Substance Registry System: 3-(thiophen-2-yl)-1,2-benzisothiazole 1,1-dioxide(124401-05-4)

Safety Data

• Hazardous Substances Data: 124401-05-4(Hazardous Substances Data)

Upstream product

• 81-07-2 saccharin 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 2786-01-8 (4-trifluoromethylphenyl)lithium 
• 567-19-1 3-chloro-1,2-benzisothiazole 1,1-dioxide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 18712-15-7 3-ethoxy-benzo[d]isothiazole 1,1-dioxide 

Relevant articles and documents

B(C6F5)3-Catalyzed Reduction of Cyclic N-Sulfonyl Ketimines

A metal-free method for reduction of cyclic N-sulfonyl ketimines catalyzed by B(C6F5)3, using commercially available methylphenylsilane as a reducing reagent under mild conditions has been developed. This reductive protoco

Enantioselective Access to Spirocyclic Sultams by Chiral Cpx-Rhodium(III)-Catalyzed Annulations

Chiral spirocyclic sultams are a valuable compound class in organic and medicinal chemistry. A rapid entry to this structural motif involves a [3+2] annulation of an N-sulfonyl ketimine and an alkyne. Although the directing-group properties of the imino group for C-H activation have been exploited, the developments of related asymmetric variants have remained very challenging. The use of rhodium(III) complexes equipped with a suitable atropchiral cyclopentadienyl ligand, in conjunction with a carboxylic acid additive, enables an enantioselective and high yielding access to such spirocyclic sultams.